Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1993-08-30
1995-03-21
Lone, Werren B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
568587, 568704, 435184, 435190, C07C20519
Patent
active
053997905
ABSTRACT:
Compounds such as 1-(4'-nitrophenyl)-2-propen-1-ol are disclosed which are non-steroidal mechanism-based inactivators of rat liver 3.alpha.-hydroxysteroid dehydrogenase. The corresponding ketones are time dependent inactivators of cyclooxygenase (PGH.sub.2 -synthase).
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Penning Trevor M.
Ricigliano Joseph W.
Lone Werren B.
Trustees of the University of Pennsylvania
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