Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-03-09
2010-06-22
McIntosh, III, Traviss C (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S023100, C536S029200
Reexamination Certificate
active
07741294
ABSTRACT:
This invention provides compositions of matter that, when incorporated into an oligonucleotide, present to a complementary strand in a Watson-Crick pairing geometry a pattern of hydrogen bonds that is different from the pattern presented by adenine, guanine, cytosine, and thymine. Most specifically, this invention discloses and claims compositions of matter that present the same hydrogen bonding patterns as the isocytidine and isoguanosine nucleobases, but do not have unfavorable tautomeric forms, do not become disassociated from their sugar, and do not make major groove interactions, as much, as easily, or as strongly as isocytidine and isoguanosine.
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Seela et al., “7-Deazaisoguanisine quartets”, Chemical Communications, 1997, 1869-70, vol. 19.
Voegel, Von Krosigk, Benner (1993) Synthesis & tautomeric equilibrium of 6-amino-5-benzyl-3-methylpyrazin-2-one. J. Org. Chem. 58, 7542-7.
Krosigk, Benner (1995) pH-independent triple helix formation by an oligonucleotide containing a pyrazine donor-donor-acceptor base. J. Am. Chem. Soc. 117, 5361-5362.
Havemann, Hoshika, Hutter, Benner (2008) Incorporation of multiple sequential pseudothymides by DNA polymerases & their impact. Nucleos.Nucleot. Nucl. Acids 27, 261-8.
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