Non-spectrophotometric measurement of analyte concentrations and

Details Non-spectrophotometric measurement of analyte concentrations and Non-spectrophotometric measurement of analyte concentrations and

1993-10-01

1995-07-18

Dzierzynski, Paul M.

Radiant energy

Invisible radiant energy responsive electric signalling

Infrared responsive

356405, G01N 2135

Patent

active

054344123

ABSTRACT:
Improvements in non-invasive detection methods for glucose and other constituents of interest in a sample have been developed. The apparatus and methods of the invention provide an analog of color perception of human vision, preferably in the near infrared region, replacing spectrophotometers and narrow band sources used in other non-invasive near infrared detection methods. A plurality of detector units are used, each covering a broad and overlapping region of the detected spectrum, paralleling color perception and colorimetry. The improvements are primarily concerned with improving the signal-to-background (or noise) ratio such that the data stream is improved. These improvements use congruent sampling, comparison of different data streams from different sample portions or filter sets, using an interrogation system with sufficient speed to allow testing of arterial blood, and using a filter with a spectral structure. In some circumstances, a neural net is used for analysis, allowing the system to learn. A novel method for background discrimination is also described.

REFERENCES:
patent: 4178917 (1979-12-01), Shapiro
patent: 4278538 (1981-07-01), Lawrence et al.
patent: 4286327 (1981-08-01), Rosenthal et al.
patent: 4520265 (1985-05-01), Griggs et al.
patent: 4543481 (1985-09-01), Zwick
patent: 4641973 (1987-02-01), Nestler et al.
patent: 4655225 (1987-04-01), Dahne et al.
patent: 4799795 (1989-01-01), Fateley
patent: 4850365 (1989-07-01), Rosenthal
patent: 4882492 (1989-11-01), Schlager
patent: 4928014 (1990-05-01), Rosenthal
patent: 4975581 (1990-12-01), Robinson et al.
patent: 5028787 (1991-07-01), Rosenthal et al.
patent: 5054487 (1991-10-01), Clarke
patent: 5070874 (1991-12-01), Barnes et al.
patent: 5321265 (1994-06-01), Block
Dufort and Lumsden, "Color categorization and color constancy in a neutral network model of V4", Biol. Cybern., vol. 65, pp. 293-303, (1991).
Rubner and Schulten, "A Regularized Approach to Color Constancy", Biol. Cybern., vol. 61, pp. 29-36, (1989).
Schmitt, "Simple Photon Diffusion Analysis of the Effects of Multiple Scattering on Pulse Oximetry", IEEE Transactions on Biomedical Engineering, vol. 38, No. 12, p. 1194, (1991).
Wukitsch et al., "Pulse Oximeter: Analysis of Theory, Technology, and Practice", J. clin. Monit., vol. 4, pp. 290-301, (1988).
Moore et al., "A Real-Time Neural System for Color Constancy", Abstract, IEEE Transactions on Neural Networks, vol. 2, No. 2, (1991).
Brochure--Minolta Chroma Meter CR-200.
Brochure--Minolta CHroma Meter CR-200.
Anal. Chem. 1990, 62, 1977-1982.
Journal of Molecular Structure, 247 (1991) 293-303.
A Fast Spectrum-Recovery Method for Hadamard Transform Spectrometers Having Nonideal Masks, S. A. Dyer, et al. Applied Spectroscopy, vol. 43, 435-440.

Affiliated with

Also associated with

Rating

Non-spectrophotometric measurement of analyte concentrations and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-spectrophotometric measurement of analyte concentrations and, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-spectrophotometric measurement of analyte concentrations and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2419802