Non-solvated crystalline form "A" of 3-(4-cynnamyl-1-piperazinyl

Details Non-solvated crystalline form "A" of 3-(4-cynnamyl-1-piperazinyl Non-solvated crystalline form "A" of 3-(4-cynnamyl-1-piperazinyl

1990-08-28

1992-03-10

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540457, C07D49822, A61K 31495

Patent

active

050951084

ABSTRACT:
The non-solvated crystalline form "A" of 3-(-4-cynnamyl-1-piperazinyl)-iminomethylrifamycine SV finds application in the therapeutical practice.
It represents a crystalline substance with absorption maximum of the infrared spectrum at 1644, 1585, 1340, 1350, 1295 and 1290-doublet, 1238, 1213, and triplet with low intesitivety at 726, 735 and 760 cm.sup.-1, as well as with characteristic diffraction maxima at 9,25 and 9,50 .theta.--most-intensive at 12,22 and doublet at 13,10 and 13,33 .theta. of the X-ray diffraction diagram.
The obtaining of the non-solvated crystalline form "A" consists in the isolation of 3-(-4-cynnamyl-1-piperazinyl)-iminomethylrifamycine obtained in medium of indifferent organic solvent, preferably tetrahydrofuran or chloroform, and its dissolution in isopropanol or acetone or a mixture of both at a temperature from 30.degree. C. up to the ebullition temperature of the respective solvent.
The substance possesses a high resoptionability, a high serum concentration, stability and chemical resistance.

REFERENCES:
patent: 4193920 (1980-03-01), Konstantinova et al.
patent: 4774237 (1988-09-01), Ueno et al.
patent: 4876258 (1989-10-01), Kump et al.
Konstantinova et al., CA 93-72212p, (1980).
Dimova et al., CA 106-12417m, (1987).

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