Non-signal imidazole reagents for mass spectrometry analysis...

Chemistry: analytical and immunological testing – Peptide – protein or amino acid

Reexamination Certificate

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C435S006120, C436S518000

Reexamination Certificate

active

08003395

ABSTRACT:
Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-compounds simultaneously.

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patent: 2004/0157344 (2004-08-01), Wang et al.
Flarakos, J. A deoxynucleotide derivatization methodology for improving LC-ESI-MS detection.Analytical Chemistry, vol. 77, No. 8, pp. 2373-2380; 2005.
Lan, Zhang-Hua et al. Matrix-assisted laser desorption/ionization mass spectrometry of deoxynucleotides labeled with an IMI dye.Rapid Comm. Mass. Spectrom, vol. 13, pp. 1454-1457; 1999.
Wang, P. et al. Phosphate-specific fluorescence labeling under aqueous conditions.Analytical Chemistry, vol. 65, No. 23, pp. 3518-3520; 1993.

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