Non-reventing live vaccines

Details Non-reventing live vaccines Non-reventing live vaccines

1991-08-16

1993-05-11

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

424 87, 424 92, 4351721, 435245, 435879, 4352523, 935 1, 935 9, 935 31, 935 58, 935 65, 935 72, C12N 1500

Patent

active

052100359

ABSTRACT:
Live vaccines are provided and methods for preparing the live vaccines for protection of a host from a pathogenic microorganism. The vaccines are prepared by introducing at least one modification in a gene involved in at least one, normally at least two, biosynthetic pathways involving the production of products which are unlikely to be found in the disease susceptible host. The modification results in a gene change which cannot be repaired by a single step, e.g. polynucleotide deletions and inversions. Where the aro gene suffers such a change, the resultant auxotrophic mutants require aromatic amino acids, p-aminobenzoic acid and 2,3-dihydroxybenzoic acid or a highly concentrated source of absorabable iron. The auxotrophic mutations have substantially reduced or nonexistent virulence while retaining the desired immunogenicity to initiate the immunogenic response. Various techniques can be employed for providing the desired change.

Affiliated with

Also associated with

Rating

Non-reventing live vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-reventing live vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-reventing live vaccines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1349732