Surgery – Truss – Pad
Patent
1985-02-27
1986-10-14
Howell, Kyle L.
Surgery
Truss
Pad
436 56, A61B 502
Patent
active
046166580
ABSTRACT:
A safe and inexpensive method of measuring blood flow in experimental animals using non-radioactively labeled microspheres is provided. The microspheres may be comprised of a variety of materials, including latex and agarose, and may be labeled with colored dyes or by linkage to enzymes, plant enzymes being preferred because they do not occur naturally in an animal's system. After injection and circulation of the microspheres throughout the animal's system, blood flow to particular tissue may be measured by counting the number of microspheres in the tissue sample, the initial number of microspheres in the animal's blood stream having been measured shortly after injection. In the case of microspheres labeled with colored dyes, the spheres may be counted in tissue either after separation from the tissue or while still trapped in the tissue's capillaries. Techniques for separating the microspheres from blood and tissue are also provided.
REFERENCES:
MacFarland, W. J. et al., "Telemetry of Regional Tissue Blood Flow Using Hydrogen Clearance", Conf: 8th Anm. NE Biongi. Conf., Cambridge, Mass. 27-28 Mar. 1980 (pp. 40-43).
Jacobs, R. et al., "Determination of Acurocies of Dye Dilution and Electromagnetic Flowmeter Methods of Measuring Blood Flow", Jrnl of TCV Surgery v. 58, No. 4, 10/1964.
See Jackie R.
Shell William
Howell Kyle L.
Jaworski Francis J.
Schaap Robert J.
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