Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2005-05-24
2005-05-24
Seidel, Marianne C. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
active
06897242
ABSTRACT:
Compositions of non-racemic mixtures of d- and l-methadone and a method of treating pain using the composition. The composition is especially useful for treating pain of mixed origin. For predominantly neuropathic pain, a mixture of predominantly d-methadone, up to about 90%, is used. For predominantly somatic pain, a mixture of predominantly l-methadone, up to about 90%, is used. The non-racemic mixture of d- and l-methadone may be further combined with a pharmacologically effective amount of a nonopioid component. In another aspect of the invention, the methadone can be combined with an opioid antagonist such as naloxone, naltrexone, or the like.
REFERENCES:
patent: 6008258 (1999-12-01), Inturrisi
Gorman et al. The d- and l- isomers of methadone bind to teh non-competetive site on the n-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord, Feb. 14, 1997, Neuroscience Letters 223 pp. 5-8.*
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Y. Eugene Mironer et al., “Successful Use of Methadone in Neuropathic Pain: A Multicenter Study by the National Forum of Independent Pain Clinicians”, Pain Digest, 1999, vol. 9, pp. 191-193.
Mironer Eugene Y.
Somerville Judson J.
Crowell & Moring LLP
Jagoe Donna
Seidel Marianne C.
LandOfFree
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