Non-racemic hexafluoroleucine, and methods of making and...

Details Non-racemic hexafluoroleucine, and methods of making and... Non-racemic hexafluoroleucine, and methods of making and...

2006-11-07

2006-11-07

Keys, Rosalynd (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Esters having the thiocarboxylate group, -cx-, wherein the...

C560S019000, C560S043000, C560S047000, C560S048000, C560S155000, C560S156000, C560S172000, C562S433000, C562S456000, C562S457000, C562S553000, C564S123000, C564S163000

Reexamination Certificate

active

07132559

ABSTRACT:
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluorleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbonfluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.

REFERENCES:
patent: 3997609 (1976-12-01), Martini et al.
patent: 4028405 (1977-06-01), Kollonitsch et al.
patent: 4325961 (1982-04-01), Kollonitsch et al.
patent: 4405530 (1983-09-01), Gerhart
patent: 4418077 (1983-11-01), Bey et al.
patent: 4695588 (1987-09-01), Kollonitsch et al.
CA:128:128262 abs of Helvetica Chimia Acta by Zhang et al 81(1) pp. 174-181, 1998.
CA:120:123831 abs of Journal of Chromatography by Vlasakova et al 639(2) pp. 273-279, 1993.
CA:87:68600 abs of Yuki Gosei Kagaku Kyokai Shi by Maki et al 34(10) pp. 722-725, 1976.
Zhang et al., Asymmetric Synthesis of (S)-5,5,5,5′, 5′, 5′-Hexafluoroleucine, Jan. 1998, Helvetica Chimica Acta, vol. 81(1), pp. 174-181.
Vlasakova et al., Insitute of Nuclear Biology and Radiochemistry, Czech Academy of Sciences, Videnska 1083, Prague, 14220/4, Czech., Journal of Chromatography (1993), 639(2), 273-9, CODEN: JOCRAM; ISSN: 0021-9673.
Zhang et al., Department Chemie Biochemie, Universtat Bern, Bern CH-3012, Switz., Helvetica Chimica Acta (1998), 81(1), 174-181, CODEN: HCACAV; ISSN: 0018-019X.
Maki et al., Ind. Res. Inst., Nagoya, Japan, Yuki Gosei Kagaku Kyokai Shi (1976), 34 (10), 722-5, CODEN: YGKKAE.
International Search Report, international application No. PCT/US02/05386.

Affiliated with

Also associated with

Rating

Non-racemic hexafluoroleucine, and methods of making and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-racemic hexafluoroleucine, and methods of making and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-racemic hexafluoroleucine, and methods of making and... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3631316