Non-peptidic surrogates of the Arg-Gly-Asp sequence and pharmace

Details Non-peptidic surrogates of the Arg-Gly-Asp sequence and pharmace Non-peptidic surrogates of the Arg-Gly-Asp sequence and pharmace

1992-11-19

1994-10-04

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514 20, 514822, 530322, 562560, A61K 3700, A61K 3702, C07C25906, C07C27904

Patent

active

053526678

ABSTRACT:
Non-peptidic RXD analogues are provided that inhibit biological cellular and molecular interactions which are dependent on RXD recognition, wherein X is one of the amino acid residues G, E, Y, A or F. In particular, RGD surrogates are provided having no sequence of .alpha.-natural amino acids and comprising a guanidino and a carboxyl terminal groups spaced by a chain of 11 atoms, at least 5 of which are carbon atoms. The compounds inhibit cell adhesion and are useful for the treatment of several pathological disorders, e.g., thrombosis, autoimmune diseases, metastasis, allergy, host-graft reactions and inhibition of scar tissue formation.

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