Non-peptide tachykinin receptor antagonists

Details Non-peptide tachykinin receptor antagonists Non-peptide tachykinin receptor antagonists

1995-06-05

1997-09-23

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514307, 514339, 514314, 514414, 544143, 546146, 546175, 5462775, 548454, 548455, 548467, A61K 3140, C07D295108

Patent

active

056704992

ABSTRACT:
This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiological disorders as well as pharmaceutical formulations which employ these novel compounds.

REFERENCES:
patent: 4757151 (1988-07-01), Horwell
patent: 5102667 (1992-04-01), Dubroeucq et al.
patent: 5137873 (1992-08-01), Yankner
patent: 5164372 (1992-11-01), Matsuo et al.
patent: 5187156 (1993-02-01), Matsuo et al.
B.D. Gitter, et al., "Species Differences in Affinities of Non-Peptide Antagonists for Substance P Receptors", European Journal of Pharmacology, 197:237-238 (1991).
D. Jukic, et al., "Neurokinin Receptors Antagonists: Old and New", Life Sciences, 49:1463-1469 (19910.
C.A. Maggi, et al., "Tachykinin Receptors and Tachykinin Receptor Antagonists", Journal of Autonomic Pharmacology, 13:23-93 (1993).

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