Non-peptide tachykinin receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514316, 514255, 514616, 514617, 514626, 514630, 514418, 514443, 514470, 514469, 548507, 548491, 548484, 548485, 548486, 546187, 544373, 564155, 564157, 549466, 549467, 549 51, 549 52, 549 54, 549 55, C07D20914, C07D40112, C07D40312, A61K 3140

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active

056840330

ABSTRACT:
This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiological disorders as well as pharmaceutical formulations which employ these novel compounds.

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B.D. Gitter, et al., "Species Differences in Affinities of Non-Peptide Antagonists for Substance P Receptors", European Journal of Pharmacology, 197:237-238 (1991).
D. Jukic, et al., "Neurokinin Receptors Antagonists: Old and New", Life Sciences, 49:1463-1469 (1991).
C.A. Maggi, et al., "Tachykinin Receptors and Tachykinin Receptor Antagonists", Journal of Autonomic Pharmacology, 13: 23-93 (1993).
Maggi, C. A. et al. J. Autonomic Pharmacol. 13, 23-93 (1993).
Saito, I. et al. Chemical Abstract 73: 110093 (1970), as searched in File CAPLUS.

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