Non-peptide peptidomimetics and related cyclic hexapeptides

Details Non-peptide peptidomimetics and related cyclic hexapeptides Non-peptide peptidomimetics and related cyclic hexapeptides

1996-01-19

1998-09-22

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Somatostatin ; related peptides

530313, 530321, 530329, 514 11, 514 17, C07K 764, C07K 14655

Patent

active

058115129

ABSTRACT:
Compounds are provided which are crossreactive with peptides such as those which bind G-protein-linked receptors, together with preparative and therapeutic methods therefor.

REFERENCES:
patent: 3721633 (1973-03-01), Ranauto
patent: 3723617 (1973-03-01), Sutton
patent: 4522813 (1985-06-01), Nutt
patent: 4798821 (1989-01-01), Hartmann
PCT International Search Report dated Jul. 11, 1997, 1 page.
Berridge, et al., "Litium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands", Biochem. J., 1982, 206, 587-595.
Cascieri, et al., "Molecular Characterization of a Common Binding Site for Small Molecules Within the Transmembrane Domain of G-Protein Coupled Receptors", J. Pharmacol. And Toxicol. Methods, 1995, 33, 179-185.
Eichler, J. And Houghten, R., "Identification of Substrate-Analog Trypsin Inhibitors Through the Screening of Synthetic Peptide Combinatorial Libraries", Biochemistry, 1993, 32, 11035-11041.
Joniak, et al., "Benzyl ethers of methyl alpha-D-glucopyroanoside", Chemical Abstracts, 1980, 93, No. 221012c, 557-558.
Kosikova, et al., "Thermal degradation of 4-O-benzyl ethers of methyl alpha-D-gblucopyranoside", Chemical Abstracts, 1979, 90, No. 13923d, 77.
The Merck Index, 9th Ed., Windholz, et al., Eds., New Jersey: Merck & Co., Inc. 576, No. 4290.
Nicolau, et al., "Design and synthesis of a peptidomimetic employing beta-D-glucose for scaffolding", Peptides, River, et al., Eds., ESCOM, 1990.
Raynor, et al., "Analogs of Somatostatin Selectively Label Distinct Subtypes of Somatostatin Receptors in Rat Brain", J. Pharmacol. & Experimental Therapeutics, 1989, 251, 510-517.
Reisine, et al., "The Localization of Receptor Binding Sites in the Substantia Nigra and Striatum of the Rat", Brain Research, 1979, 117, 241.
Rich, D.H., Protease Inhibitors, Barrett, et al., Eds., Elsevier, 1986.
Sherman, et al., "Compatibility of Thioamides with Reverse Turn Features: Synthesis and Conformational Analysis of Two Model Cyclic Pseudopeptides Containing Thioamides as Backbone Modifications", J. Am. Chem. Soc., 1990, 112, 433-441.
Thorsett, et al., "Dipeptide Mimics. Conformationally Restricted Inhibitors of Angiotensin-Converting Enzyme", Biochem. Biophys. Res. Comm., 1983, 111, 166-171.
Veber, et al., "Conformationally restricted bicyclic analogs of somatostatin", Proc. Natl. Acad. Sci. USA, 1978, 75, 2636-2640.
Veber, et al., "A Super Active Cyclic Hexapeptide Analog of Somatostatin", Life Sciences, 1984, 34, 1371-1378.
Veber, et al., "A potent cyclic hexapeptide analogue of somatostatin", Nature, 1981, 292, 55-58.
Hirschmann et al. `Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of Minilibrary in Transforming a Peptidal Somatostain Receptor Ligand into an NK-1 Receptor Ligand Via a Polyvalent peptidomimetic` J. Med. Chem. vol. 39, pp. 2441-2448, 1996.

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