Non-peptide GNRH agents, methods and intermediates for their...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S487000, C549S488000, C514S461000, C514S370000, C514S336000, C514S444000, C514S255050, C514S394000, C548S195000, C548S304700, C544S152000, C544S405000, C546S233000, C546S284700, C546S060000

Reexamination Certificate

active

07101878

ABSTRACT:
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

REFERENCES:
patent: 3907700 (1975-09-01), Grier
patent: 3932444 (1976-01-01), Ellis
patent: 4013647 (1977-03-01), Sellstedt et al.
patent: 4076718 (1978-02-01), Sellstedt et al.
patent: 5236928 (1993-08-01), Chakravarty et al.
patent: 5780393 (1998-07-01), Newton
patent: 5834482 (1998-11-01), Lundbeck et al.
patent: 5981521 (1999-11-01), Haviv et al.
patent: 1 267 583 (1972-03-01), None
patent: 1 491 776 (1977-11-01), None
patent: WO 97/21707 (1997-06-01), None
patent: WO 97/44339 (1997-11-01), None
Parce et al., Science, 1989, 246:243-247.
B.E. Howland et al., Experentia, 1974, 1223-1225.
Bernatowicz et al., J. Org. Chem., 1992, 57:2497-2502.
Mndzhoyan et al., Chem., Abstr., 1962, vol. 57, No. 9, 11137.
Goulet, M.T., Ann. Reports Med. Chem., 1995, vol. 30, Chap. 18, 169-177.
Abdel-Magid et al., J. Org. Chem. 1996, 61:3849-3862.
Owicki et al., Ann. Rev. Biophys. Biomol. Struc., 1994, 23:87-113.
Pitchford et al., Am. J. Physiol., 1995, 268, (Cell Physiol. 37), C936-C943.
Parlow, Tetrahedron, 1993, vol. 49 (13), 2577-2588.
Drake et al., Synth., 1994, 579-582.
Marelli et al., Arch. Ital. Urol., 1997, 69 (4), 257-263.
Jungwirth et al., Prostrate, 1997, 32 (3), 164-172.
Sralovic et al., Int. J. Oncol., 1998, 12 (3), 489-498.
Kottler et al., Int. J. Cancer, 1997, 71 (4), 595-599.
Bowers et al., Endocrinology, 1980, 106 (3):674-683.
Corbin et al., Endocr. Res. Commun., 1975, 2 (1):1-23.
Still et al., J. Org. Chem., 1978, 43:2923-2925.
Cheng et al., Biochemical Pharmacology, 1973, 22:3099-3108.
Mndzhoyan et al., Khim.-Farm. Zh., 1988, vol. 22, No. 9, 1091-1094.
Mndzhoyan et al., Khim.-Farm. Zh., 1986, vol. 20, No. 4, 446-450.

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