Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Patent
1996-02-01
1999-12-28
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
558156, 558158, 558159, 558160, 558161, 558162, 558163, 558164, 558165, C07F 9141, C07F 9143, C07F 9145, C07F 940
Patent
active
060083980
ABSTRACT:
A phosphorus ester oligomer having the structure: wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substituted or unsubstituted arylamino and aminoalkyl; B.sub.1 and B.sub.2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labeling group, a protecting group, a phosphoramidate or a phosphomonoester; R.sub.1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R.sub.1 is independently selected from the group consisting of (i) a non-vicinal diol attached to a hydrogen bond donor functionality; (ii) a hydrogen bond acceptor selected from an ether; (iii) a non-vicinal diol attached to a hydrophobic functionality or a vicinal diol attached to an aliphatic or alicyclic hydrophobic functionality (iv) a diol attached to a ring substituted anionic functionality and (v) a cationic moiety attached to a non-vicinal or alicyclic diol, any of which can further include a detectable label, and n is at least two. Preferred R.sub.1 moieties include condensation products of alicyclic diols and polycyclic diols; also the non-nucleotide monomers thereof, and the use of the oligomers as selective target-binding compounds.
Cook Alan F.
Fathi Reza
Gentles Robert Gerard
Rudolph Morris Jonathan
Genzyme Corporation
Olstein Elliot M.
Oswecki Jane C.
Richter Johann
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