Non-nucleotide phosphorus ester oligomers

Details Non-nucleotide phosphorus ester oligomers Non-nucleotide phosphorus ester oligomers

1995-01-18

1999-07-06

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558156, 558158, 544243, 544265, 544337, 544358, 544398, 546 22, 546 24, 548112, 5483411, 549218, 549475, 549502, C07F 906, C07F 9141, C07D23360, C07D24104

Patent

active

059199652

ABSTRACT:
A phosphorus ester oligomer having the structure: ##STR1## wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, alkyl- or aryl-substituted amino and aminoalkyl; B.sub.1 and B.sub.2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labelling group, a protecting group, a phosphoramidate or a phosphomonoester; R.sub.1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R.sub.1 is independently selected from the group consisting of a condensation product of (i) a non-vicinal diol attached to a hydrogen bond donor functionality; (ii) a hydrogen bond acceptor selected from an ether, a purine or pyrimidine substituted 1,2-diol or a disubstituted heterocycle; (iii) a non-vicinal diol attached to a hydrophobic functionality or a vicinal diol attached to an aliphatic or alicyclic hydrophobic functionality (iv) a diol attached to a ring substituted anionic functionality and (v) a cationic moiety attached to a non-vicinal or alicyclic diol, any of which can further include a detectable label, and n is at least one. Preferred R.sub.1 moieties include condensation products of heterocyclic diols, alicyclic diols, and polycyclic diols. Also the non-nucleotide monomers thereof, combinatorial library mixtures of the oligomers and the use of the oligomers as selective target-binding compounds.

REFERENCES:
patent: 5364564 (1994-11-01), Koga

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