Non-nucleotide linking reagents for nucleotide probes

Details Non-nucleotide linking reagents for nucleotide probes Non-nucleotide linking reagents for nucleotide probes

1997-08-07

2000-02-29

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 243, 536 2431, 536 2432, 536 2533, 558 70, 558199, 558202, 562 8, 562 10, 562 23, C07H 2100, C07F 902

Patent

active

06031091&

ABSTRACT:
A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide
on-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.

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