Non-nucleotide containing RNA

Details Non-nucleotide containing RNA Non-nucleotide containing RNA

2005-02-01

2005-02-01

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S025300, C536S025310, C536S022100, C435S006120

Reexamination Certificate

active

06849726

ABSTRACT:
The present invention relates to RNA molecules containing one or more non-nucleotide mimetics.

REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5672501 (1997-09-01), Matulic-Adamic et al.
patent: 5891683 (1999-04-01), Usman et al.
patent: 6117657 (2000-09-01), Usman et al.
patent: 6362323 (2002-03-01), Usman et al.
patent: 0 360 257 (1990-03-01), None
patent: 0 519 463 (1992-12-01), None
patent: WO 8902439 (1989-03-01), None
patent: WO 9103162 (1991-03-01), None
patent: WO 9207065 (1992-04-01), None
patent: WO 9315187 (1993-08-01), None
patent: WO 9323569 (1993-11-01), None
patent: WO 9402595 (1994-02-01), None
patent: WO 9413688 (1994-06-01), None
Brown et al.,“Expr ssion of the c-myb Proto-oncogene in Bovine Vascular Smooth Muscle Cells,” J. Biol. Chem. 267:4625-4630 (1992).
Chowrira et al., NAR 20:2835 (1990).
Cload and Schepartz, “Polyether Tethered Oligonucleotide Probes,” J. Am. Chem. Soc. 113:6324-6326 (1991).
Collins and Olive, “Reaction Conditions and Kinetics of Self-Cleavage of a Ribozyme Derived From Neurospora VS RNA,” Biochemistry 32:2795-2799 (1993).
Durand et al., “Circular Dichroism Studies of an Oligodeoxyribonucleotide Containing a Hairpin Loop Made of a Hexaethylene Glycol Chain: Conformation and Stability,” Nucleic Acids Research 18:6353-6359 (1990).
Ferentz and Verdine, “Disulfied Cross-Linked Oligonucleotides,” J. Am. Chem. Soc. 113:4000-4002 (1991).
Guerrier-Takada et al., “The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme,” Cell 35:849-857 (1983).
Hampel et al., “‘Hairpin’ Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA,” Nucleic Acids Research 18:299-304 (1990).
Hampel and Tritz, “RNA Catalytic Properties of the Minimum (−)sTRSV Sequence,” Biochemistry 28:4929-4933 (1989).
Haseloff and Gerlach, “Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities,” Nature 334:585-591 (1988).
Iyer et al., “Abasic Oligodeoxyribonucleoside Phosphorothioates: Synthesis and Evaluation as Anti-HIV-1 Agents,” Nucleic Acids Research 18:2855-2859 (1990).
Jaschke et al., “Automated Incorporation of Polyethylene Glycol into Synthetic Oligonucleotides,” Tetrahedron Letters 34:301-304 (1993).
Jeffries and Symons, “A Catalytic 13-mer Ribozyme,” Nucleic Acids Research 17:1371-1377 (1989) (also referred to as Jefferies).
Kiso et al., “Acetonation of Some Pentoses with 2,2-Dimethoxypropane-N,N-Dimethylformamide-p-Toluenesulfonic Acid” Carbohydrate Research 52:95-101 (1976).
Ma et al., “Design and Synthesis of RNA Miniduplexes via a Synthetic Linker Approach. 2. Generation of Covalently Closed, Double-Stranded Cyclic HIV-1 TAR RNA Analogs with High Tat-Binding Affinity,” Nucleic Acids Research 21:2585-2589 (1993).
Ma et al., “Design and Synthesis of RNA Miniduplexes via a Synthetic Linker Approach,” Biochemistry 32:1751-1758 (1993).
McCurdy et al., “Deoxyoligonucleotides with Inverted Polarity: Synthesis and Use in Triple-Helix Formation” Nucleosides & Nucleotides 10:287-290 (1991).
Millican et al., “ Synthesis and Biophysical Studies of Short Oligodeoxynucleotides with Novel Modifications: a possible Approach to the Problem of Mixed Based Oligodeoxynucleotides Synthesis,” Nucleic Acids Research 12:7435-7453 (1984).
Nielsen et al., “Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide,” Science 254:1497 (1991).
Ono et al., “DNA Triplex Formation of Oligonucleotid Analogues Consisting of Linker Groups and Octamer Segments That Have Opposite Sugar-Phosphate Backbone Polarities,” Biochemistry 30:9914-9921 (1991).
Paolella et al., “Nuclease Resistant Ribozymes with High Catalytic Activity,” EMBO Journal 11:1913-1919 (1992).
Perreault et al., “Mixed Deoxyribo- and Ribo-Oligonucleotides with Catalytic Activity,” Nature 344:565-567 (1990) (often mistakenly listed as Perrault).
Perreault et al., “Relationship between 2′-Hydroxyls and Magensium Binding in the Hammerhead RNA Domain: A Model for Ribozyme Catalysis,” Biochemistry 30:4020-4025 (1991).
Perrotta and Been, “Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis δ Virus RNA Sequence,” Biochemistry 31:16-21 (1992).
Pieken et al., “Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes,” Science 253:314-317 (1991).
Richardson and Schepartz, “Tethered Oligonucleotide Probes. A Strategy for the Recognition of Structured RNA,” J. Am. Chem. Soc. 113:5109-5111 (1991).
Robins et al., “Nucleic Acid Related Compounds, 42. A General Procedure for the Efficient Deoxygenation of Secondary Alcohols. Regiospecific and Stereoselective Conversion of Ribonucleosides to 2′-Deoxynucleosides” J. Am. Chem. Soc. 105:4059-4065 (1983).
Rossi et al., “Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems,” Aids Research and Human Retroviruses 8:183-189 (1992).
Salunkhe et al., “Control of Folding and Binding of Oligonucleotides by Use of a Nonnucleotide Linker,” J. Am. Chem. Soc. 114:8768-8772 (1992).
Sarver et al., “Catalytic RNAs (Ribozymes): A New Frontier in Biomedical Applications,” AIDS Res. Revs. 2:259-285 (1992).
Saville and Collins, “A Site-Specific Self-Cleavage Reaction Performed by a Novel RNA In Neurospora Mitochondria,” Cell 61:685-696 (1990).
Saville and Collins, “RNA-Mediated Ligation of Self-Cleavage Products of a Neurospora Mitochondrial Plasmid Transcript,” Proc. Natl. Acad. Sci. USA 88:8826-8830 (1991).
Scaringe et al., “Chemical synthesis of biologically active oligoribonucleotides using β-cyanoethyl protected ribonucleoside phosphoramidites,” Nucl Acids Res. 18:5433-5441 (1990).
Seela and Kaiser, Nucleic Acids Res. 1990, 18:6353.
Seela and Kaiser, “Oligodeoxyribonucleotides containing 1,3-propanediol as nucleoside substitute,” Nucleic Acids Research 15:3113-3129 (1987).
Stull and Szoka, “Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Progress and Prospects,” Pharmaceutical Research 12:465-483 (1995).
Takeshita et al., “Oligedoxynucleotides Containing Synthetic Abasic Sites,” The Journal of Biological Chemistry 262:10171-10179 (1987).
Uhlenbeck, “A Small Catalytic Oligoribonucleotide,” Nature 328:596-600 (1987) (this is listed as Nature 327 in the various specifications, but it is actually 328).
Usman and Cedergren, “Exploiting the chemical synthesis of RNA,” TIBS 17:334-339 (1992).
Usman et al., “Automated Chemical Synthesis of Long Oligoribonucleotides Using 2′-O-Silylated Ribonucleoside 3′-O-Phosphoramidites on a Controlled-Pore Glass Support: Synthesis of a 43-Nucleotide Sequence Similar to the 3′-Half Molecule of anEscherichia coliFormylmethoionine tRNA,” J. Am. Chem. Soc. 109:7845-7854 (1987).
Usman et al., “Chemical modification of hammerhead ribozymes: activity and nuclease resistance,” Nucleic Acids Syposium Series 31:163-164 (1994).
Yang et al., “Minimum Ribonucleotide Requirement for Catalysis by the RNA Hammerhead Domain,” Biochemistry 31:5005-5009 (1992).
Zuckerman et al., “Efficient Method for the Preparation of Peptoids [Oligo (N-Substituted Glycines)]by Submonomer Solid-Phase Synthesis,” J. Am. Chem. Soc. 114:10464 (1992).

Affiliated with

Also associated with

Rating

Non-nucleotide containing RNA does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-nucleotide containing RNA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-nucleotide containing RNA will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3452095