Non-nucleotide containing enzymatic nucleic acid

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 4351723, 4351721, 4352401, 536 231, 536 232, 536 245, 514 44, C12P 1934, C12Q 168, C07H 2102, A01N 4304

Patent

active

058916830

ABSTRACT:
Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.

REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5672501 (1997-09-01), Matulic-Adamic et al.
Robins et al. "Nucleic acid related compounds. 42. A general procedure for the efficient deoxygenation of secondery alcohols. Regiospecific and stereoselective conversion of ribonucleosides to 2'-deoxynucleosides" J. Am. Chem. Soc. vol. 105, pp. 4059-406, 1983.
Kiso et al. "Acetonation of some pentoses with 2,2-dimethoxypropane-N-,N-dimethylformamide-p-toluenesulfonic acid" Carbohydrate Research, vol. 52, pp. 95-101, 1976.
Takeshita et al. "Oligodeoxynucleotides containing synthetic abasic sites" The Journal of Biological Chemistry, vol. 262, pp. 10171-10179, 1987.
Millican et al. "Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis" Nucleic Acids Research, vol. 12, pp. 7435-7453, 1984.
Iyer et al. "Abasic oligodeoxyribonucleoside phosphorothioates: Synthesis and evaluation as anti-HIV-1 agents" Nucleic Acids Research, vol. 18, pp. 2855-2859, 1990.
Brown et al., "Expression of the c-myb Proto-oncogene in Bovine Vascular Smooth Muscle Cells," J. Biol. Chem. 267:4625-4630 (1992).
Cload and Schepartz, "Polyether Tethered Oligonucleotide Probes," J. Am. Chem. Soc. 133:6324 (1991).
Collins and Olive, "Reaction Conditions and Kinetics of Self-Cleavage of a Ribozyme Derived From Neurospora VS RNA," Biochemistry 32:2795-2799 (1993).
Durand et al., "Circular Dichroism Studies of an Oligodeoxyribonucleotide Containing a Hairpin Loop Made of a Hexaethylene Glycol Chain: Conformation and Stability," Nucleic Acids Research 18:6353 (1990).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585-591 (1988).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1989).
Nielsen et al., "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide," Science 254:1497 (1991).
Paolella et al., Nuclease Resistant Ribozymes with High Catalytic Activity EMBO J. 11:1913-1919 (1992).
Perreault et al., "Mixed Deoxyribo- and Ribo-Oligonucleotides with Catalytic Activity," Nature 344:565-567 (1990).
Perreault et al., "Relationship between 2'-Hydroxyls and Magensium Binding in the Hammerhead RNA Domain: A Model for Ribozyme Catalysis, " Biochemistry 30:4020-4025 (1991).
Pieken et al., "Kinetic Characterization of Ribonuclease-Resistant 2'-Modified Hammerhead Ribozymes," Science 253:314-317 (1991).
Salunkhe et al., "Control of Folding and Binding of Oligonucleotides by Use of a Nonnucleotide Linker," J. Am. Chem. Soc. 114:6324 (1992).
Sarver et al., "Catalytic RNAs (Ribozymes): A New Frontier in Biomedical Applications," AIDS Res. Revs. 2:259 (1992).
Saville and Collins, "A Site-Specific Self-Cleavage Reaction Performed by a Novel RNA In Neurospora Mitochondria," Cell 61:685-696 (1990).
Saville and Collins, "RNA-Mediated Ligation of Self-Cleavage Products of a Neurospora Mitochondrial Plasmid Transcript," Proc. Natl. Acad. Sci. USA 88:8826-8830 (1991).
Scaringe et al., "Chemical synthesis of biologically active oligoribonucleotides using .beta.-cyanoethyl protected ribonucleoside phosphoramidites," Nucl Acids Res. 18:5433-5441 (1990).
Seela and Kaiser, "Oligodeoxyribonucleotides containing 1,3-propanediol as nucleoside substitute," Nucleic Acids Research 15:3113 (1990).
Uhlenbeck, "A Small Catalytic Oligoribonucleotide," Nature 328:596-600 (1987).
Usman and Cedergren, "Exploiting the chemical synthesis of RNA," TIBS 17:334-339 (1992).
Usman et al., "Automated Chemical Synthesis of Long Oligoribonucleotides Using 2'-O-Silylated Ribonucleoside 3'-O-Phosphoramidites on a Controlled-Pore Glass Support: Synthesis of a 43-Nucleotide Sequence Similar to the 3'-Half Molecule of an Escherichia coli Formylmethoionine tRNA," J. Am. Chem. Soc. 109:7845-7854 (1987).
Usman et al., "Chemical modification of hammerhead ribozymes: activity and nuclease resistance," Nucl. Acid. Symp. Genes 31:163-164 (1994).
Yang et al., "Minimum Ribonucleotide Requirement for Catalysis by the RNA Hammerhead Domain," Biochemistry 31:5005-5009 (1992). (N-Substituted Glycines)! by Submonomer Solid-Phase Synthesis," J. Am. Chem. Soc. 114:10464 (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Non-nucleotide containing enzymatic nucleic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-nucleotide containing enzymatic nucleic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-nucleotide containing enzymatic nucleic acid will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1370395

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.