Non-nucleosidic coumarin derivatives as polynucleotide-crosslink

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 245, 549280, 549289, 558199, C07H 2104

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060050934

ABSTRACT:
Novel coumarin derivatives comprising a coumarin moiety linked to a non-nucleosidic backbone moiety are disclosed. The resulting molecules are typically used as photoactivate cross-linking groups when incorporated into polynucleotides as replacements for one or more of the complementary nucleoside bases present in probes used in procedures involving nucleic acid hybridization reactions.

REFERENCES:
patent: 4196281 (1980-04-01), Hearst et al.
patent: 4378458 (1983-03-01), Gohlke et al.
patent: 4599303 (1986-07-01), Yabusaki et al.
patent: 4617261 (1986-10-01), Sheldon, III et al.
patent: 4713326 (1987-12-01), Dattagupta et al.
patent: 4737454 (1988-04-01), Dattagupta et al.
patent: 4822731 (1989-04-01), Watson et al.
patent: 4826967 (1989-05-01), Glass
patent: 5026840 (1991-06-01), Dattagupta et al.
patent: 5082934 (1992-01-01), Saba et al.
patent: 5112963 (1992-05-01), Pieles et al.
patent: 5124246 (1992-06-01), Urdea et al.
Clontech Catalog 94/95, pp. 709, 113-116.
Ou et al. (I), "Photobinding of 8-Metoxypsoralens and 5,7-Dimethoxycoumarin to DNA and Its Effect on Template Activity," Biochemistry, 17(6), 1047-1053 (1978).
Ou et al. (II), "Photobinding of 8-Methoxypsoralens to Transfer RNA and 5-Fluorouracil-Enriched Transfer RNA," Biochemistry, 17(6), 1054-1059 (1978).
Lown et al., "Photoreactions of Psoralen and Other Furocoumarins With Nucleic Acids," Bioorg. Chem., 7(1), 85-95 (1978); Chem. Abstr., 88, p. 259, Abstr. No. 184809s (1978); Only Abstract provided.
Seidel et al. (I), "Nucleic Acid Base Specific Quenching of a Coumarin-120-Derivative in Nucleotide-Conjugates-Photoinduced Electron Transfer?" Proc. SPIE-Int. Soc. Opt. Eng., (Biomol. Spectrose. 2), 1991, 91-104.
Seidel et al. (II), "Characterization of Fluorescence-Labeled DNA by Time Resolved Fluorescence Spectoscopy," Proc. SPIE-Int. Soc. Opt. Eng., (Biomol. Spectrosc. 2), 1991, 105-116.
Alves, "A Chemical Method of Labeling Oligodeoxyribonucleotides with Biotin: A Single Step Procedure Using a Solid Phase Methodology," Tett. Lett., 30(23), 3089-3092 (1989).
Boiziau et al., "Mechanisms of the Inhibition of Reverse Transcriptase by Antisense Oligonucleotides," Proc. Nat. Acad. Sci. USA, 89, 768-772 (1992).
Cimino et al., "Psoralens as Photoactive Probes of Nucleic Acid Structure and Function: Organic Chemistry, Photochemistry, and Biochemistry," Ann. Rev. Biochem., 54, 1151-1193 (1985).
Cocuzza, "A Phosphoramidite Reagent for Automated Solid Phase Synthesis of 5'-Biotinylated Oligonucletides," Tett. Lett., 30(46), 6287-6290 (1989).
Gamper et al., "Solution Hybridization of Crosslinkable DNA Oligonucleotides to Bacteriophage M 13 DNA--Effect of Secondary Structure on Hybridization Kinetics and Equlibria," J. Mol. Biol., 197, 349-362 (1987).
Goodchild, "Conjugates of Oligonucleotides and Modified Oligonucleotides: A Review of Their Synthesis and Properties," Bioconjugate Chem., 1(3), 165-187 (1990).
Haralambidis et al., "The Preparation of Polyamide-Oligonucleotide Probes Containing Multiple Non-radioactive Labels," Nucleic Acids Res., 18(3), 501-505 (1990).
Lee et al., "Interaction of Psoralen-Derivatized Oligodeoxyribonucleoside Methylphosphonates with Single-Stranded DNA," Biochemistry, 27, 3197-3203 (1988).
Misiura et al., "Biotinyl and Phosphotyrosinyl Phosphoramidite Derivatives Useful in the Incorporation of Multiple Reported Groups on Synthetic Oligonucleotides," Nucleic Acids Res., 18(15), 4345-4354 (1990).
Nelson et al. (I), "A New and Versatile Reagent for Incorporating Multiple Primary Aliphatic Amines into Synthetic Oligonucleotides," Nucleic Acids Res., 17(18), 7179-7186 (1989).
Nelson et al. (II), "Bifunctional Oligonucleotide Probes Synthesized Using a Novel CPG Support Are Able to Detect Single Base Pair Mutations," Nucleic Acids Res., 17(18), 7187-7194 (1989).
Nelson et al. (III), "Oligonucleotide Labelling Methods. 3. Direct Labeling of Oligonucleotides Employing a Novel, Non-Nucleosidic, 2-Amino-1,3-propanediol Backbone," Nuclkeic Acids Res., 20(23), 6253-6259 (1992).
Pieles et al. (I), "Psoralen Covalently Linked to Oligodeoxyribonucleotides: Synthesis, Sequence Specific Recognition of DNA and Photo-Cross-Linking to Pyrimidine Residues of DNA," Nucleic Acids Res., 17(1), 285-299 (1989).
Pieles et al. (II), "Preparation of a Novel Psoralen Containing Deoxyadenosine Building Block for the Facile Solid Phase Synthesis of Psoralen-Modified Oligonucleotides for a Sequence-Specific Crosslink or a Given Target Sequence," Nucleic Acids Res., 17(22), 8967-8978 (1989).
Takasugi et al., "Sequence-Specific Photo-Induced Cross-Linking of the Two Strands of Double-Helical DNA by a Psoralen Covalently Linked to a Triple Helix-Forming Oligonucleotide," Proc. Nat. Acad. Sci. USA, 88, 5602-5606 (1991).
Suortti et al., "Necatorin, A Highly Mutagenic Compound from Lacarius Necator," Phytochemistry, 22(12), 2873-2874 (1983).

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