Non-nucleoside reverse transcriptase inhibitors

Details Non-nucleoside reverse transcriptase inhibitors Non-nucleoside reverse transcriptase inhibitors

2007-03-13

2007-03-13

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S247000, C544S114000, C544S239000

Reexamination Certificate

active

10807993

ABSTRACT:
This invention relates to novel pyridazinone derivatives of formula I wherein R1–R4, R7, R8and X1are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula I, pharmaceutical compositions containing of formula I admixed with at least one solvent, carrier or excipient and processes to prepare compounds of formula I. The compounds are useful for treating disorders in which HIV and genetically related viruses are implicated

REFERENCES:
patent: 5886178 (1999-03-01), Allen et al.
patent: WO 96/24343 (1996-08-01), None
patent: WO 96/34851 (1996-11-01), None
patent: WO 97/02023 (1997-01-01), None
patent: WO 97/02024 (1997-01-01), None
patent: WO 01/85670 (2001-11-01), None
Marcus et al., PubMed Abstract (Intervirology, 45(4-6):260-6), 2002.
Miles, Medline Abstract (Community Pract. vol. 78, Issue 8, pp. 292-294) Aug. 2005.
van Heeswijk et al., PubMed Abstract (Antivir. Ther. 6(4):201-29) Dec. 2001.
West, Solid Solutions, Solid State Chemistry and its applications, pp. 358 and 365, 1986.
Vippagunta et al., Crystalline Solids, Advanced Drug Delivery Reviews, 48, pp. 3-26, 2001.
Ulrich, Chapter 4: Crystallization, Kirk-Othmer Encyclopedia of Chemical Technology, Aug. 2002.
De Clercq, Erik, “New Developments in Anti-HIV Chemotherapy,”Current Medicinal Chemistry, 2001,.pp. 1543-1572, vol. 8 No. 13.
Leeson, Paul D., “Selective Thyromimetics. Cardiac-Sparing Thyroid Hormone Analogues Containing 3′-Arylmethyl Substituents,”J. Med. Chem., 1989, pp. 320-336, vol. 32, No. 2.
Buckheit, Jr., Robert W., “Non-nucleoside reverse transcriptase inhibitors: perspectives on novel therapeutic compounds and strategies for the treatment of HIV infection,”Expert Opin. Investig. Drugs, Ashley Publications Ltd., 2001, pp. 1423-1442, vol. 10, No. 8.
Chintakunta, V.K., et al, “3-O-Substituted benzyl pyridazinone derivatives as COX inhibitors”,Eur. J. Med. Chem., 37(4):339-347, 2002.

Affiliated with

Also associated with

Rating

Non-nucleoside reverse transcriptase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-nucleoside reverse transcriptase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-nucleoside reverse transcriptase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3777035