Non-nucleoside 1,3-diol reagents and their use to label or modif

Details Non-nucleoside 1,3-diol reagents and their use to label or modif Non-nucleoside 1,3-diol reagents and their use to label or modif

1997-10-14

1999-08-24

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 2531, 536 2534, 536 254, 428402, 435 6, 501 33, 560155, C07H 2100, B32B 516

Patent

active

059426101

ABSTRACT:
The subject invention concerns novel reagents and methods useful for introducing functional groups and labels at multiple sites of a nucleotide. The reagents are useful, for example, in constructing labeled oligonucleotide hybridization probes for detecting the presence of a target polynucleotide in biological or chemical samples.

REFERENCES:
patent: 5141813 (1992-08-01), Nelson
patent: 5451463 (1995-09-01), Nelson et al.
Nelson et al., Nucl. Acids Res. 17:7179-7186 (1989).
Misiura et al., Nucl. Acids Res. 18:4345-4354 (1990).
Zuckerman et al., Nucl. Acids Res. 15:5305-5321 (1987).
Smith et al., Nucl. Acids Res. 13:(7) 2399-2412 (1985).
Cocuzza, Tetrahedron Letters, 30(46):6287-6290 (1989).
Sanders et al., Nucl. Acids. Res. 17(15):6087-6102 (1989).
Zimran et al., Nucl. Acids. Res. 17(18):7538 (1989).

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