Non-natural C-linked carbo-β-peptides with robust...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides containing saccharide radicals – e.g. – bleomycins – etc.

Reexamination Certificate

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C530S332000, C530S333000, C530S335000, C530S337000, C530S343000, C930S030000, C930S290000

Reexamination Certificate

active

07001982

ABSTRACT:
Nonnatural C-linked carbo-β-peptides with robust secondary structures, which involves the synthesis of a new class of β-peptides called C-linked carbo-β-peptides. The compounds are favorably disposed for the formation of stable helical structures and are useful as biologically active carbo-β-peptides. The new class of β-peptides have the following formulaThe new class of β-peptides are useful as biologically active molecules to disrupt biological interactions of proteins, for molecular design and to synthesize peptide libraries.

REFERENCES:
patent: 6060585 (2000-05-01), Gellman et al.
patent: 6617425 (2003-09-01), Seebach
patent: 6677431 (2004-01-01), DeGrado et al.
Drey et al. Synthesis of Beta-Amino-Acid Peptides . . . Journal of the Chemical Society, Perkins Transactions I. 1973, pp. 2001-2006.
Sharma, G., et al., “Robust Mixed 10/12 Helices Promoted by “Alternating Chirality” in a New Family of C-Linked Carbo-beta.-peptides” XP-002300147Journal of the American Chemical Society(2003) vol. 125, No. 45, pp. 13670-13671.
Palomo, C., “Design and Synthesis of a Novel Class of Sugar-Peptide Hybrids . . . ”Journal of the American Chemical Society(2002) vol. 124, No. 29, pp. 8637-8643, XP009010582.
Jablonkai, I., “New Approach for Preparation of C-Glycoamino Acid Building Blocks”American Peptide Society(2001) pp. 52-53, XP009037661.
Sharma, G., et al., “Tetra-n-butylammonium fluoride: an efficient base for aza-Michael addition . . . ”Tetrahedron: Asymmetry(2002) vol. 13, No. 1, pp. 21-24.
Seebach, D., et al., “Preparation and Structure of beta-Peptides Consisting of Geminally . . . ”Helvetica Chimica Acta(1998) vol. 81, pp. 2218-2243, XP-001182275.

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