Non-metabolizable clomiphene analogs for treatment of tamoxifen-

Details Non-metabolizable clomiphene analogs for treatment of tamoxifen- Non-metabolizable clomiphene analogs for treatment of tamoxifen-

1994-12-05

1997-10-28

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514649, A61K 31135

Patent

active

056818637

ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each selected from the group consisting of C.sub.1 -C.sub.2 lower alkyl; X is NH or S; and n is a whole number within the range of 1-4 inclusive; and when n=0, X is (CH.sub.2).sub.3 and the pharmaceutically acceptable salts thereof have been shown to be effective in treating tamoxifen resistant tumors.

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