Non-malignant cells coupled to adjuvants and their use in a meth

Details Non-malignant cells coupled to adjuvants and their use in a meth Non-malignant cells coupled to adjuvants and their use in a meth

1990-12-10

1993-05-04

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 424 90, 424 91, 424 92, 424 93, 530402, 530403, 530404, 530405, 530406, 512 2, 4352401, A61K 3900, A61K 3702

Patent

active

052080226

ABSTRACT:
A vaccine composition for inducing anti-tumor immunity comprising non-malignant cells, preferably syngeneic mon-malignant cells, coupled with adjuvant compounds. The nonmalignant immunizing cells of the present invention induce T-cell mediated cytoxicity which cross-reacts with tumor cells, providing in vivo protection against the tumor cells. Examples of turmors which may be treated by administration of the vaccine compositions include fibrosarcomas, glioblastomas, and all solid and lymphoid tumors.

REFERENCES:
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Toubiana et al, Cancer Immunol. Immunother, vol. 2, pp. 189-193, 1977.
Yorkoni et al, J. Natl. Cancer Inst. vol. 51, pp. 717-720, 1973.
Kotani et al, Federation Proc. vol. 45, pp. 2534-2540, 1986.
Adam et al, Molec. Cell. Biochem, vol. 41, pp. 27-47, 1981.
Eggers et al, Cancer Immunol. Immunother. vol. 19, pp. 43-45, 1985.
Glimcher et al, Journal Experimental Medicine, vol. 154, pp. 1652-1670, Nov. 1981.
Eggers et al., Journal of Biological Response Modifiers, vol. 3, pp. 387-390, 1984.
Schinder et al, Int. J. Immunopharamac. vol. 8, No. 5, pp. 487-498, 1986.

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