Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1993-09-13
1996-05-07
Stoll, Robert L.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
600 1, 4241301, 4241411, 4241781, 4241831, 4241521, 4241531, 4241541, 604 20, A61K 4300, A61K 3100, A61N 500
Patent
active
055143644
ABSTRACT:
The present invention relates to non-lethal methods of conditioning a recipient for bone marrow transplantation. In particular, it relates to the use of sublethal doses of total body irradiation, cell type-specific antibodies, especially antibodies directed to bone marrow stromal cell markers, cytotoxic drugs, or a combination thereof. The methods of the invention have a wide range of applications, including, but not limited to, the conditioning of an individual for hematopoietic reconstitution by bone marrow transplantation for the treatment of hematologic malignancies, hematologic disorders, autoimmunity, infectious diseases such as acquired immunodeficiency syndrome, and the engraftment of bone marrow cells to induce tolerance for solid organ, tissue and cellular transplantation.
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patent: 5273738 (1993-12-01), Matthews et al.
Pierce et al., "Effects of Thy-1.sup.+ Cell Depletion . . . ," Transplantation, vol. 48(2), Aug. 1989, pp. 289-296.
Gassmann et al., "Immune Reactivity after High-Dose Irradiation", Transplantation, vol. 41(3), Mar. 1986, pp. 380-384.
Pierce et al., "The Role of Donor Lymphoid Cells . . . , " Transplantation, vol. 40(6), Dec. 1985, pp. 702-707.
Nakamura et al., "Graft Rejection by Cytolytic T Cells . . . ", Transplantation, vol. 49(2), Feb. 1990, pp. 453-458.
Down et al., "Synogenic and Allogenic Bone Marrow Engraftment After Total Body Irradiation", Blood, vol. 77(3), Jan. 1, 1991, pp. 661-669.
Chapman Lara E.
Stoll Robert L.
University of Pittsburgh
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