Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1994-11-14
1997-06-03
Kight, John
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
4241301, 4241411, 4241521, 4241531, 4241541, 4241781, 4241811, 4241831, 600 1, 604 20, A61K 4300, A61K 3100, A61K 500
Patent
active
056351569
ABSTRACT:
The present invention relates to non-lethal methods of conditioning a recipient for bone marrow transplantation. In particular, it relates to the use of nonlethal doses of total body irradiation, total lymphoid irradiation cell type-specific antibodies, especially antibodies directed to bone marrow stromal cell markers, cytotoxic drugs, or a combination thereof. The methods of the invention have a wide range of applications, including, but not limited to, the conditioning of an individual for hematopoietic reconstitution by bone marrow transplantation for the treatment of hematologic malignancies, hematologic disorders, autoimmunity, infectious diseases such as acquired immunodeficiency syndrome, and the engraftment of bone marrow cells to induce tolerance for solid organ, tissue and cellular transplantation.
REFERENCES:
patent: 4500637 (1985-02-01), Neville, Jr. et al.
patent: 4998931 (1991-03-01), Slichter et al.
patent: 5178858 (1993-01-01), Reichert et al.
patent: 5187266 (1993-02-01), Farguhar et al.
patent: 5273738 (1993-12-01), Matthews et al.
patent: 5374658 (1994-12-01), Lau
patent: 5504092 (1996-04-01), Nilsson et al.
patent: 5514364 (1996-05-01), Ildstad
Down et al., "Synogeneic and Allogeneic Bone Marrow Engraftment After Total Body Irradiation," Blood, 77(3), Jan. 1, 1991, pp. 661-669.
Pierce et al., "Effects of Thy-1.sup.+ Cell Depletion . . . ", Transplantation, 48(2), Aug. 1989, pp. 289-296.
Gassmann et al., "Immune Reactivity After High-Dose Irradiation," Transplantation, 41(3), Mar. 1986, pp. 380-384.
Pierce et al., "The Role of Donor Lymphoid Cells . . . ", Transplantation, 40(6), Dec. 1985, pp. 702-707.
Nakamura et al., "Graft Rejection by Cytolytic T Cells . . . ," Transplantation, 49(2), Feb. 1990, pp. 453-458.
Antin et al., "Selective Depletion of Bone Marrow T Lymphocytes . . . ," Blood, 78(8), 1991, pp. 2139-2149, abstracted in Biosis 92:6551.
Chapman Lara E.
Kight John
University of Pittsburgh
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