Surgery – Radioactive substance applied to body for therapy
Patent
1997-12-11
2000-03-21
Winakur, Eric F.
Surgery
Radioactive substance applied to body for therapy
128898, A61N 500
Patent
active
060396849
ABSTRACT:
The present invention relates to the use of a non-lethal preparative regimen for the treatment of a patient with human immunodeficiency virus (HIV) disease. In a clinical trial, an HIV-positive patient was conditioned by non-lethal doses of irradiation and a chemotherapeutic drug prior to receiving donor bone marrow cells from a baboon. While long-term engraftment of donor cells was not observed, the non-lethal preparative conditioning regimen was able to reduce the viral burden and improved the clinical outcome. Such method is useful for treatment of patients with advanced acquired immunodeficiency syndrome (AIDS).
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Bergheim Olav B.
Ildstad Suzanne T.
Allegheny University of the Health Sciences
Chimeric Therapies, Inc.
Winakur Eric F.
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