Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Utility Patent
1997-02-03
2001-01-02
Harrison, Robert H. (Department: 1617)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C514S159000, C514S844000, C514S859000
Utility Patent
active
06168798
ABSTRACT:
FIELD OF THE INVENTION
The invention relates generally to compositions and methods for topical application to the skin to treat conditions, such as acne, which often cause blemishes, pimples and redness.
BACKGROUND OF THE INVENTION
Aging, hormonal changes, and approaching adolescence often cause unsightly and embarrassing skin conditions which take the form of pimples, blemishes, pustules and reddened areas. These skin problems take their toll not only in emotional anxiety and distress but also in physical marring of the skin, sometimes associated with pain, in both juveniles and adults. Age-related skin problems can arise either from disease or illness, or as a consequence of hormonal changes. Skin problems can be exacerbated by environmental influences such as, for example, improper diet, stress or tension, and lack of sleep. Disease conditions include dry skin, ichthyosis, eczema, palmar and plantar hyperkeratoses, dandruff, acne and warts. Skin changes associated with aging can result in such symptoms as age spots, wrinkling and related aging changes.
A number of issued patents disclose the use of &agr;-hydroxy acids and salts such as lactic and glycolic acids, for the treatment of diseased and nondiseased skin and wrinkles (U.S. Pat. Nos. 4,105,782, 4,105,783, 4,021,572, 3,879,537, 3,920,835, 3,984,566 and 3,988,470 to Van Scott and Yu and U.S. Pat. No. 5,091,171 to Yu et al.). These patents focus primarily on &agr;-hydroxy acids of lower molecular weight. Ammonium salts were found to be more effective than the free acid, and both of the aforementioned forms were said to be substantially better than the alkali metal salts. A problem with the use of these compounds is that the levels at which the &agr;-hydroxy acids are most effective in commercial products results in a stinging sensation and even redness after application on the skin. Indeed, the stinging and redness is reputed to be an indication to the user that the product is working. However, those who use products containing &agr;-hydroxy acids and salts and apply them to their skin would rather have performance without such side effects.
Compositions and methods for the treatment of acne vulgaris are disclosed in U.S. Pat. No. 4,536,399 to Flynn et al., which describes the combination of benzoyl peroxide or salicylic acid with fumed silica intended to treat oily skin. Benzoyl peroxide based anti-acne compositions with irritation suppressants are described in U.S. Pat. No. 4,545,990 to Le Poyer de Cosul et al. U.S. Pat. No. 4,608,370 to Aronsohn describes the removal of at least some blemishes and the imparting of a useful, healthy complexion with a composition of salicylic acid, resorcinol, lactic acid and ethyl alcohol. U.S. Pat. No. 5,482,710 to Slavtcheff et al. discloses cosmetic compositions which include at least one keratolytic agent (e.g., the &bgr;- and &agr;-hydroxy carboxylic acids, e.g., salicylic acid and glycolic or lactic acid) and a combination of water soluble and water insoluble anti-irritancy agents, such as a salt of glycyrrhizinic acid and &agr;-bisabolol, respectively). Other anti-acne treatments are reported in U.S. Pat. Nos. 4,613,592 and 4,772,592 to Benzoni. These treatments utilize C
1
-C
4
alkyl lactates as the active ingredient in a water-in-oil emulsion.
U.S. Pat. No. 5,057,502 to Walsh describes the use of Juniper extract materials to reduce thin heavy oily, greasy secretions from the skin. Co-actives are reported to be vitamin A, aloe vera and camomile extract. Pulverized flowers are reported in the skin treatments of U.S. Pat. Nos. 4,880,621 and 4,933,177 to Grollier et al. Although many of the above-described treatment compositions and methods may prove useful, they suffer from slow performance and/or unsatisfactory results, or have unacceptable qualities, as perceived by the user.
Thus, it is clear that the art is in need of cosmetic formulations and compositions to reduce or eliminate skin conditions, such as blemishes and redness, without producing irritation, stinging, or further redness to the skin. The formulations should work to mitigate such skin conditions within a short time period after application. The formulations should provide a good feeling to the user after application and, ideally, should control sebum production and should not leave the skin looking shiny after application. Further, the formulations should not deposit a greasy or oily film or residue on the skin surface.
SUMMARY OF THE INVENTION
The present invention provides a cosmetic composition for application on the skin for reducing and eliminating skin conditions, such as acne and its associated blemishes and redness. It is an object of the present invention to provide stable and nonirritating formulations for cosmetic use that function to reduce and eliminate pimples, blemishes and redness within a short period of time after topical application. More particularly, an object of the invention is to provide a non-irritating anti-acne astringent for topical application on the skin which contains component ingredients which reduce and/or alleviate irritation and burning sensations on the skin.
It is another object of the present invention to provide a clear, hydroalcoholic cosmetic composition containing a C
2
-C
18
polyhydric alcohol phosphate ester, a disaccharide polyol phosphate ester, or said esters as a salt complex of a mono- or divalent metal ion for the treatment of pimples, blemishes and redness which feels comfortable and clean to the user after application and which avoids undesirable side effects such as stinging, burning, and brightened skin color.
It is also an object of the invention to avoid greasy or oily residues on the skin after application of the cosmetic compositions described herein. In accordance with the invention, the compositions optimally dry quickly and cleanly (without visible residue or stickiness) after application on the skin.
It is yet another object of the invention to provide effective anti-acne formulations which are milder than other compositions in the art, which actively mitigate skin conditions for which they are being used, and which substantially alleviate or minimize stinging or burning sensation upon or after application on the skin of the user.
It is still yet another object of the invention to provide methods for reducing skin irritation after topical application of an anti-acne or skin treatment composition by applying the above-mentioned non-irritating compositions formulated in accordance with the invention.
Further objects and advantages afforded by the invention will be apparent from the detailed description hereinbelow.
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Chemical Abstracts, 125:123723.
Chemical Abstracts, 125:150778.
Chemical Abstracts, 125:150779
Chemical Abstracts, 125:150780.
Chemical Abstracts, 125:150781.
Chemical Abstracts, 128:106418.*
Mayes-Smith Joyce
O'Halloran David P.
Rudtke Deborah
Bristol--Myers Squibb Company
Harrison Robert H.
Zeller Charles J.
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