Non-ionic surfactants for poorly soluble molecules

Details Non-ionic surfactants for poorly soluble molecules Non-ionic surfactants for poorly soluble molecules

2004-04-13

2009-02-17

Carr, Deborah D (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

C554S219000, C554S227000, C424S439000, C514S784000

Reexamination Certificate

active

07491836

ABSTRACT:
New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene/alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3—(CH2)x—CH—(CH2)y—CO—[—O—R3—]z—O—R1R2—O (I); wherein for example R1is methyl, R2is optionally substituted C14-C22acyl, alkyl, or alkenyl, R3is ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.

REFERENCES:
patent: 4366151 (1982-12-01), Oppenlaender et al.
patent: 6365637 (2002-04-01), Zirnstein et al.
patent: 17059 (1981-11-01), None
Janssen et al., Biotech. Letters, “Lipase-Catalyzed Synthesis of oleic acid esters of polyethylene glycol 400”, vol. 16, No. 2, pp. 163-168, 1994.
Lorenz, W. et al., National Library of Medicine (NLM), file Medline, Medline accession No. 6177219.
STN International, file CAplus, CAplus accession No. 1999:431639, Document No. 131:86938.
Database WPI, Week 199624, Derwent Publications Ltd., London, GB, AN 1996-233354 & JP 80-89263 A.
Database WPI, Week 198422 Derwent Publications Ltd., GB; AN 1984-136506 & JP 59-069135A.
Database WPI, Week 199538 Derwent Publications Ltd., London GB; AN 1995-287977 & JP 71-84672A.
“The Theory and Practice of Industrial Pharmacy” 2nded., Lea & Febiger, 1976, p. 108-111.
Lorentz et al., “Agents and Actions”, vol. 12, ½, 1982, p. 64-80.
Vulfson, “Novel Surfactants”, Holmberg editor, Marcel Dekker, 1988, p. 279-97.
Yalkowsky, “Solubility & Solubilization in Aqueous Media”, American Chemical Society and Oxford University Press, 1999, p. 312-320.
“Surface Active Agents (non-ionic)- Determination of Polyethylene Glycols and Non-Ionic Active Matter (adducts)- Weibull Method”, International Standard Organization, ISO-2268:1972(E).
US Pharmacopeia 24, 2000, p. 10.
Corswant et al., “Triglyceride Based Microemulsion . . . ”, J. Pharm. Sci., 1998, 87(2), p. 200-8.
Mosharraf and Nyström, “The Effect of Particle . . . ”, Int. J. Pharm., 1995, 122, p. 35-47.
Östh, Karin, Thesis: The Horizontal Ussing Chamber Method in Studies of Nasal Drug Delivery, 2002, Faculty of Pharmacy, Uppsala University; and attached papers: Paper I: Östh et al., J. Pharm. Sci., vol. 91, No. 5, May 2002 Paper II: Östh et al., J. Controlled Release, 83, (2002), 377-388 Paper III: Östh et al., “Uptake of ovalbumin-conjugated starch microparticles by pig respiratory nasal mucosa in vitro” (manuscript submitted for publication) Paper IV: Östh et al., “Correlation between epithelial toxicity and surfactant structure derived from studies of polyoxyethylene oxide and their effects on Caco-2 cells and pig nasal mucosa” (manuscript).

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