Non-ionic contrast media from ionic contrast media

Details Non-ionic contrast media from ionic contrast media Non-ionic contrast media from ionic contrast media

1990-09-14

1991-07-30

Elmore, Carolyn

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

564153, C07C23746, A61K 31165, A61K 4904

Patent

active

050358774

ABSTRACT:
Novel non-ionic contrast media are efficiently prepared from generally available ionic contrast media. Particularly, polyhydroxyhalohydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.

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Havaaveldsen et al., Acta Pharm. Suec. 20, 232, (1983), pp. 219-232.

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