Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-08-09
2005-08-09
Goldberg, Jeanine A. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S004000, C435S091100, C435S091200, C536S023100, C536S024300
Reexamination Certificate
active
06927028
ABSTRACT:
In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic differences in the DNA species such as differences in DNA methylation. In a second aspect, the present invention features methods of detecting genetic abnormalities in a fetus by detecting fetal DNA in a biological sample obtained from a mother. In a third aspect, the present invention features methods for differentiating DNA species originating from an organ donor from those of an organ recipient. In a fourth aspect, the present invention features kits for differentiating DNA species originating from different individuals in a biological sample.
REFERENCES:
patent: 6258540 (2001-07-01), Lo et al.
patent: WO 98/39474 (1998-09-01), None
Mangioni et al., “Long-term Persistence of Hemopoietic Chimerism Following Sex-Mismatched Bone Marrow Transplantation”Bone Marrow Transplant, 20:969-973 (1997).
Roux et al., “Evolution of Mixed Chimerism After Allogenic Bone Marrow Transplantation as Determined on Granulocytes and Mononuclear Cells by the Polymerase Chain Reaction”Blood, 79:2775-2783 (1992).
Lo et al., “Presence of Fetal DNA in Maternal Plasma and Serum”Lancet, 350:9076:485-487 (1997).
Lo et al., “Prenatal Diagnosis of Fetal RhD Status by Molecular Analysis of Maternal Plasma ”N Eng J Med, 339(24):1734-1738 (1998).
Faas et al., “Detection of Fetal RHD-specific Sequences in Maternal Plasma”Lancet, 352(9135):1196 (1998).
Amicucci et al., “Prenatal Diagnosis of Myotonic Dystrophy Using Fetal DNA Obtained from Maternal Plasma”Clin Chem, 46(2):301 (2000).
Chen et al., “Fetal DNA in Mataernal Plasma: The Prenatal Detection of a Paternally Inherited Fetal Aneuploidy”Prenat Diagn, 20(4):355-357 (2000).
Saito et al., “Prenatal DNA Diagnosis of a Single-gene Disorder From Maternal Plasma”Lancet, 356:1170 (2000).
Lo et al., “Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis”Am J. Hum Genet, 62:768-775 (1998).
Chen et al., “Fetal DNA Analyzed in Plasma from a Mother's Three Consecutive Pregnancies to Detect Paternallyy Inherited Aneuploidy”Clin Chem, 47:937-939 (2001).
Esteller, et al., “Detection of Aberrant Promoter Hypermethylation of Tumor Suppressor Genes in Serum DNA from Non-Small Cell Lung Cancer Patients”Cancer Res, 59(1):67-70 (1999).
Wong et al., “Detection of Aberrant p16 Methylation in the Plasma and Serum of Liver Cancer Patients”Cancer Res, 59(1):71-73 (1999).
Wolffe et al., “Epigenetics: Regulation Through Repression”Science, 286:481-486 (1999).
Wolffe, “Transcriptional Control: Imprinting Insulation”Curr Biol., 10:R463-R465 (2000).
Lo, et al., “Quantitative Analysis of the Bidirectional Fetomaternal Transfer of Nucleated Cells and Plasma DNA”Clin Chem, 46(9):1301-1309 (2000).
Maloney et al., “Microchimerism of Maternal Origin Persists into Adult Life”J Clin Invest, 104(1):41-47 (1999).
Lo et al., “Application of a Polymorphic Y Microsatellite to the Detection of Post Bone Marrow Transplantation Chimaerism”Br J Haematol,89(3):645-649 (1995).
Lo et al., “Presence of Donor-specific DNA in Plasma of Kidney and Liver-transplant Recipients”Lancet, 351(9112):1329-1330 (1998).
Zhang et al., “Presence of Donor-and Recipient-derived DNA in Cell-free Urine Samples of Renal Transplantation Recipients: Urinary DNA Chimerism”Clin Chem, 45(10):1741-1746 (1999).
Ohgane et al., “Analysis of CpG Islands of Trophoblast Giant Cells by Restriction Landmark Genomic Scanning”Dev Genet, 22(2):132-140 (1998).
Tang et al., “Detection of Fetal-derived Paternally Inherited X-Chromosome Polymorphisms in Maternal Plasma”Clin Chem, 45(11):2033-2035 (1999).
Pertl et al., “Detection of Male and Female Fetal DNA in Maternal Plasma by Multiplex Fluorescent Polymerase Chain Reaction Amplification of Short Tandem Repeats”Hum Genet, 106:45-49 (2000).
Kubota et al., “Methylation-specific PCR Simplifies Imprinting Analysis”Nat Genet, 16(1):16-17 (1997).
Graves, “Genomic Imprinting, Development and Disease- is Pre-eclampsia Caused by a Maternally Imprinted Gene?”Reprod Fertil Dev, 10(1):23-29 (1998).
Yu et al., “Gene Identification and DNA Sequence Analysis in the GC-poor 20 Megabase Region of Human Chromosome 21”Proc Natl Acad Sci USA, 94(13):6862-6867 (1997).
Herman et al., “Methylation-specific PCR: A Novel PCR Assay for Methylation Status of CpG Islands”Proc Natl Acad Sci USA, 93:9821-9826 (1996).
Lo, “Fetal DNA in Maternal Plasma: Biology and Diagnostic Applications”Clin Chem, 46(12):1903-1906 (2000).
Nakagawa et al., “Loss of Imprinting of the Insulin-like Growth Factor II Gene Occurs by Biallelic Methylation in a Core Region of H19-associated CTCF-binding Sites in Colorectal Cancer”Proc Natl Acad Sci USA, 98(2):591-596 (2001).
Herman et al., “Methylation-specific PCR: A Novel PCR Assay for Methylation Status of CpG Islands”Proc Natl Acad Sci USA, 93:9821-9826 (1996).
Lo et al., “Fetal cells in Maternal Blood: Prospects for Noninvasive Prenatal Diagnosis”Ann N Y Acad Sci, 731:204-213 (1994).
Bianchi, “Fetal DNA in Maternal Plasma: The Plot Thickens and the Placental Barrier Thins”Am J Hum Genet,62:763-764 (1998).
Newton et al., “Analysis of Any Point Mutation in DNA. The Amplification Refractory Mutation System (ARMS)”Nucleic Acids Res, 17:2503-2516 (1989).
Lo et al., “Quantitative Analysis of Aberrant p16 Methylation Using Real-Time Quantitative Methylation-specific Polymerase Chain Reaction”Cancer Res, 59:3899-3903 (1999).
Eads et al., “MethyLight: A High-Throughput Assay To Measure DNA Methylation”Nucleic Acids Res, 28(8):E32 (2000).
Kawakami et al., “Hypermethylated APC DNA in Plasma and Prognosis of Patients With Esophageal Adenocarcinoma”J Natl Cancer Inst, 92(22):1805-1811 (2000).
Avent et al, “Prenatal Determination of Fetal Blood Group Status”Vox Sang, 78:155-162 (2000).
Tang et al., “Detection of Fetal-derived Paternally Inherited X-Chromosome Polymorphisms in Maternal Plasma”Clin Chem, 45(11):2033-2035 (1999).
Grunau et al., “Large-scale Methylation Analysis of Human Genomic DNA Reveals Tissue-specific Differences Between the Methylation Profiles of Genes and Pseudogenes”HumMol Genet, 9(18):2651-2663 (2000).
Poon et al., “Prenatal Detection of Fetal Down's Syndrome From Maternal Plasma”Lancet, 356:1819-1820 (2000).
Lo et al., “Increased Fetal DNA Concentrations in the Plasma of Pregnant Women Carry Fetuses with Trisomy 21”Clin Chem, 45(10):1747-1751 (1999).
Zhong et al., “Fetal DNA in Maternal Plasma is Elevated in Pregnancies with Aneuploid Fetsuses”Prenat Diagn, 20:795-798 (2000).
Van Wijk et al., “Detection of Apoptotic Fetal Cells in Plasma of Pregnant Women”Clin Chem, 46(5):729-731 (2000).
Kuromitsu et al., “A Unique Downregulation of h2-Calponin Gene Expression in Down Syndrome: A Possible Attenuation Mechanism for Fetal Survival by Methylation at the CpG Island in the Trisomic Chromosome 21”Mol Cell Biol, 17(2):707-712 (1997).
Nuovo et al., “In Situ Detection of the Hypermethylation -induced inactivation of the p16 Gene as an Early Event in Oncogenesis”Proc Natl Acad Sci USA, 96(22):12754-12759 (1999).
Lo et al., “Two-way Cell Traffic Between Mother and Fetus: Biologic and CLinical Implications”Blood, 88(11):4390-4395 (19
Dennis Lo Yuk Ming
Man Poon Lit
Chinese University of Hong Kong
Goldberg Jeanine A.
Townsend and Townsend / and Crew LLP
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