Non-invasive method of obtaining a pre-determined acoustic...

Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation

Reexamination Certificate

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Reexamination Certificate

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07837623

ABSTRACT:
A non-invasive method of obtaining a target soundwave field in the brain by means of an array of transducers positioned outside the skull, the method comprising a training stage during which, on the basis of a three-dimensional image giving the porosity of the skull at all points, digital simulation is used to determine individual sound signals to be emitted by the transducers in order to obtain the target soundwave field in the brain. After the training stage, the array of transducers is used to locate the position of the array of transducers relative to the skull by echography and to ensure that the array of transducers is accurately positioned.

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Hynynen et al., “Trans-skull Ultrasound Therapy; The Feasibility of Using Image-Derived Skull Thickness Imformation to Correct the Phase Distortion”,IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 46 No. 3, pp. 752-754, (May 1999).
Pernot, et al., “Experimental Validation of 3D Finite Differences Simulations of Ultrasonic Wave Propagation Through the Skull”, Proceeding from an IEEE conference, 4 pages, (Oct. 2001).
French Preliminary Search Report, FR 0210682; report dated May 9, 2003.
International Search Report, PCT/FR 03/02554; report dated Feb. 4, 2004.

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