Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Patent
1997-06-09
1999-03-23
Hindenburg, Max
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
356 39, A61B 500
Patent
active
058852123
ABSTRACT:
Methods and apparatus are provided for non-invasively determining blood pH by a multivariate analysis technique, such as classical least squares (CLS), partial least squares (PLS), or principal components regression (PCR). The technique employs at least one spectral factor based on the difference in the spectrum of a hemoglobin fraction (e.g., oxyhemoglobin) at two different pH's (e.g., pH 7.2 and pH 7.8). The spectral factor is preferably evaluated over the wavelength range of 520-680 nm.
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Wimberley P., et al. "Effect of pH on the Absorption Spectrum of Human Oxyhemoglobin: a Potential Source of Error in Measuring the Oxygen Saturation of Hemoglobin" Clinical Chemistry, vol. 34, No. 4 (1988) 750-754.
Alam, M.K. et al., "Near-infrared spectroscopy of lysed blood: pH effects", Proceedings SPIE, vol. 2680, Ultrasensitive biomedical diagnostics, San Jose, CA, (1996) pp. 146-155.
Haaland et al., "Partial Least-Squares Methods for Spectral Analyses. 1. Relation to Other Quantitative Calibration Methods and the Extraction of Qualitative Information", Anal. Chem., 60 (1988) pp. 1193-1202.
Owen, "Quantitative UV-Visible Analysis in the Presence of Scattering", Hewlett-Packard Application Note, publication 12-5963-3937E, 1995, pp. 0-7 .
Chiron Diagnostics Corporation
Gagnebin , III Charles L.
Hindenburg Max
Morgenstern Arthur S.
Winaker Eric F.
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