Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-09-13
2010-06-22
Huff, Sheela J (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100
Reexamination Certificate
active
07741065
ABSTRACT:
A monoclonal antibody or fragment thereof, capable of specifically binding to at least one epitope of sH2a and/or being elicited by at least one epitope, and assays, kits, and methods of use thereof diagnosing liver disease or condition, detecting liver function and assessing the efficacy of therapy to a liver disease.
REFERENCES:
patent: 4036945 (1977-07-01), Haber
patent: 4331647 (1982-05-01), Goldenberg
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5545806 (1996-08-01), Lonberg et al.
patent: 5545807 (1996-08-01), Surani et al.
patent: 5569825 (1996-10-01), Lonberg et al.
patent: 5625126 (1997-04-01), Lonberg et al.
patent: 5633425 (1997-05-01), Lonberg et al.
patent: 5661016 (1997-08-01), Lonberg et al.
patent: 0773289 (1996-08-01), None
Wisdom Clin. Chem.. vol. 22 p. 1243 (1976).
Moseley “Evaluation of Abnormal Liver Function Tests”, Management of Chronic Liver Disease, 80(5): 887-906, 1996.
Drickamer “Clearing Up Glycoprotein Hormones”, Cell, 67: 1029-1032, 1991.
Doyle et al. “Plasma Membrane: Biogenesis and Turnover”, The Liver: Biology and Pathobiology, 2nd Ed.(Chap.8): 141-163, 1988.
Gopal et al. “Abnormal Findings on Liver Function Tests: Interpreting Results to Narrow the Diagnosis and Establish A Prognosis”, Postgraduate Medicine, 107(2): 100-114, 2000.
Hay et al. “The Nature of Unexplained Chronic Aminotransferase Elevations of A Mild to Moderate Degree in Asymptomatic Patients”, Hepatology, 9(2): 193-197, 1989. Abstract.
Hayasaka et al. “Serum Markers as Tools to Monitor Liver Fibrosis”, Digestion, 59: 381-384, 1998.
Lederkremer et al. “An Alernatively Spliced Miniexon Alters the Subcellular Fate of the Human Asialglycoprotein Receptor H2 Subunit”, The Journal of Biological Chemistry, 266(2): 1237-1244, 1991.
Tolchinsky et al. “Membrane-Bound Versus Secreted Forms of Human Asialglycoprotein Receptor Subunits”, The Journal of Biological Chemistry, 271(24): 14496-14503, 1996.
Trojan et al. “Serum Tests for Diagnosis and Follow-Up of Hepatocellular Carcinoma After Treatment”, Digestion, 59(Suppl.2): 72-74, 1998.
Yago et al “Detection and Quantification of Soluble Asialglycoprotein Receptor in Human Serum”, Hepatplogy, 21:383-388, 1995.
Campbell “General Properties and Applications of Monoclonal Antibodies”, Monoclonal Antibody Technology, Elsevier Science Publishers, Chap.1: 1-32, 1984. p. 29.
Hay et al. “The Nature of Unexplained Chronic Aminotransferase Elevations of a Mild to Moderate Degree in Asymptomatic Patients”, Hepatology, 9(2): 193-197, 1989.
Supplementary European Search Report Dated Jun. 8, 2009 From the European Patent Office Re.: Application No. 04720548.9.
Bischoff et al. “The H1 and H2 Polypeptides Associate to Form the Asialoglycoprotein Receptor in Human Hepatoma Cells”, The Journal of Cell Biology, XP007898593, 106(4): 1067-1974, Apr. 1988. p. 1068, 1-h Col., Last §—r-h Col., § 1.
Henis et al. “Oligomeric Structure of the Human Asialoglycoprotein Receptor: Nature and Stoichiometry of Mutual Complexes Containing H1 and H2 Polypeptides Assessed by Fluorescence Photobleaching Recovery”, The Journal of Cell Biology, XP007908595, 111(4): 1409-1418, Oct. 1990. p. 1410, r-h Col., § 2-3.
Kokudo et al. “Predictors of Successful Hepatic Resection: Prognostic Usefulness of Hepatic Asialoglycoprotein Receptor Analysis”, Worl Journal of Surgery, XP007908592, 26(11): 1342-1347, Nov. 2002. Abstract.
International Preliminary Report on Patentability Dated Jun. 26, 2008 From the International Bureau of WIPO Re.: Application No. PCT/IL2004/000244.
International Search Report Dated Dec. 18, 2007 From the International Searching Authority Re.: Application No. PCT/IL04/00244.
Invitation to Pay Additional Fees Dated Mar. 14, 2007 From the International Searching Authority Re.: Application No. PCT/IL04/00244.
Written Opinion Dated Dec. 18, 2007 From the International Searching Authority Re.: Application No. PCT/IL04/00244.
Communication Pursuant to Article 94(3) EPC Dated Aug. 21, 2009 From the European Patent Office Re.: Application No. 04720548.9.
Response Dated Dec. 16, 2009 to Communication Pursuant to Article 94(3) EPC of Aug. 21, 2009 From the European Patent Office Re.: Application No. 04720548.9.
Kondratyev Maria
Lederkremer Gerardo Zelmar
Huff Sheela J
Ramot At Tel Aviv University Ltd.
LandOfFree
Non-invasive marker for liver function and disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Non-invasive marker for liver function and disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-invasive marker for liver function and disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4152316