Non-invasive localization of a light-emitting conjugate in a mam

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

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424 961, 4241931, 4242581, 424 932, 435 735, 435 79, 435 8, 4351723, 436800, 536 2532, A01K 4900, A01K 39385, G01N 33569, C07H 2102

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active

056501358

ABSTRACT:
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

REFERENCES:
patent: 4762701 (1988-08-01), Horan et al.
patent: 4912031 (1990-03-01), Compton et al.
Alfano, R.R., et al., "Light Sheds Light On Cancer-Distinguishing Malignant Tumors From Benign Tissues And Tumors," Bull. N.Y. Acad. Med. 37(2): 143-150 (1991).
Alfano, R.R., et al., "Fluorescence Spectra from Cancerous and Normal Human Breast and Lung Tissues," IEEE Journal of Quantum Electronics QE-23(10): 1806-1811 (1987).
Benaron, D.A., and D.K. Stevenson, "Optical Time-of-Flight and Absorbance Imaging of Biologic Media," Science 259: 1463-1466 (1993).
Casadei, J., et al., "Expression and secretion of aequorin as a chimeric antibody by means of a mammalian expression vector," Proc. Natl. Acad. Sci. USA 87: 2047-2051 (1990).
Chalfie, M., et al., "Green Fluorescent Protein as a Marker for Gene Expression," Science 263: 802-805 (1994).
Frackman, S., et al., "Cloning, Organization, and Expression of the Bioluminescence Genes of Xenorhabdus luminescens," Journal of Bacteriology 172(10): 5767-5773 (1990).
Hooper, C.E., et al., "CCD Imaging of Luciferase Gene Expression in Single Mammalian Cells," Journal of Bioluminescence and Chemiluminescence 5: 123-130 (1990).
Korpela, M., et al., "Stable-light-emitting Escherichia coli as a Biosensor," Journal of Bioluminescence and Chemiluminescence 4: 551-554 (1989).
Meighen, E.A., "Bacterial bioluminescence: organization, regulation, and application of the lux genes," The FASEB Journal 7: 1016-1022 (1993).
Mueller-Klieser, W., and S. Walenta, "Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging," Histochemical Journal 25: 407-420 (1993).
Schaefer, C., et al., "Oxygenation and Bioenergetic status of Murine Fibrosarcomas," in Oxygen Transport to Tissue XIV (Erdmann, W., and D.F. Bruley, eds., Plenum Press, New York, 1992, pp. 161-166).
Tamiya, E., et al., "Spatial imaging of luciferase gene expression in transgenic fish," Nucleic Acids Research 18(4): 1072 (1990).
Tang, G.C., et al., "Pulsed and cw laser fluorescence spectra from cancerous, normal, and chemically treated normal human breast and lung tissues," Applied Optics 28(12): 2337-2342 (1989).
Tang, G.C., et al., "Spectroscopic Differences Between Human Cancer and Normal Lung and Breast Tissues," Lasers in Surgery and Medicine 9: 290-295 (1989).
Wood, K.V., et al., "Complementary DNA Coding Click Beetle Luciferases Can Elicit Bioluminescence of Different Colors," Science 244: 700-702 (1989).
Zhang, L., et al., "Luciferase activity as a marker of tumor burden and as an indicator of tumor response to antineoplastic therapy in vivo," Clin. Exp. Metastasis 12: 87-92 (1994).
Kuhn et al, 1991, Arch. Surg. 126: 1398-1403.

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