Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2005-08-02
2005-08-02
Graser, Jennifer E. (Department: 1645)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C424S009600, C424S009610, C424S093100, C424S093200, C435S320100, C435S325000, C435S007900, C435S968000, C436S800000
Reexamination Certificate
active
06923951
ABSTRACT:
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.
REFERENCES:
patent: 4178917 (1979-12-01), Shapiro
patent: 4341223 (1982-07-01), Lutz
patent: 4541438 (1985-09-01), Parker et al.
patent: 4762701 (1988-08-01), Horan et al.
patent: 4912031 (1990-03-01), Compton et al.
patent: 5171749 (1992-12-01), Levy et al.
patent: 5281539 (1994-01-01), Schramm
patent: 5283179 (1994-02-01), Wood
patent: 5332567 (1994-07-01), Goldenberg
patent: 5418132 (1995-05-01), Olivo
patent: 5435307 (1995-07-01), Friauf et al.
patent: 5466575 (1995-11-01), Cozzette et al.
patent: 5622868 (1997-04-01), Clarke et al.
patent: 5650135 (1997-07-01), Contag et al.
patent: 5683888 (1997-11-01), Campbell
patent: 5917190 (1999-06-01), Yodh et al.
patent: 6020121 (2000-02-01), Bao et al.
patent: 6217847 (2001-04-01), Contag et al.
patent: 0 263 657 (1988-04-01), None
patent: 0 743 366 (1996-11-01), None
patent: 0 350 973 (1997-11-01), None
patent: WO 86/01805 (1986-03-01), None
patent: WO 86/01806 (1986-03-01), None
patent: WO 91/01305 (1991-02-01), None
patent: WO 96/40979 (1996-12-01), None
Aizawa et al., “A New Diagnostic System for Malignant Tumors Using Hematoporhyrin Derivative, Laser Photoradiation and a Spectroscope,”Porphyrin Localization and Treatment of Tumorspp 227-238 (1984).
Alfano et al., “Fluorescence Spectra from Cancerous and Normal Human Breast and Lung Tissues,”Journal of Quantum Electronics 23(10):1806-1811 (1987).
Alfano et al., “Light Sheds Light on Cancer-Distinguishing Malignant Tumors from Benign Tissues and Tumors,” Bull N.Y. Acad. Med. 67(2):143-150 (1991).
Anderson-Engles, S. et al., “Fluorescence Imaging and Point Measurements of Tissue; Applications to the Demarcation of Malignant Tumors and Atherosclerotic Lesions from Normal Tissue,”Photochemistry and Photobiology 53(6):807-814 (1991).
Anderson-Engles, S. et al., “Laser-induced Fluorescence in Malignant and Normal Tissue of Rats Injected with Benzoporhyrin Derivative,”Photochemistry and Photobiology 57(6):978-983 (1993).
Andrew et al., “Construction of Bioluminescent Mycobacterium and its Use for Assay of Antimycobacterial Agents,”J. Clin. Microbiol. 31(9):2251-2254 (1993).
Araki, “Photo-detection of Transferred Gene Expression in Fish,”Chemical Abstracts 123: Abstract No. 189418 (1995).
Balchum, O. et al., “Imaging Fluorescence Bronchoscopy for Localizing Early Bronchial Cancer and Carcinoma in Situ,”Porphyrin Localization and Treatment of Tumors, pp. 847-861, New York: Alan R. Liss Inc. (1984).
Ballou, B. et al., “Tumor Location and Drug Targeting Using a Monoclonal Antibody (anti-SSEA-1) and Antigen-Binding Fragments,”Journal of Surgical Oncology 31:1-12 (1986).
Ballou, B. et al., “Tumor Labeling In Vivo Using Cy5-monoclonal Antibody,”Proceedings of the American Association for Cancer Research Annual Meeting 35(O):504 (1994).
Baumgartner et al., “A Fluorescence Imaging Device for Endoscopic Detection of Early Stage Center- Instrumental and Experimental Studies,”Photochemistry and Photobiology: 46(5):759-763 (1987).
Benaron et al., “A Medical Perspective at the Threshold of Clinical Optical Tomography,”SPIE Optical Engineering Press, Pp. 3-9 (1993).
Benaron and Stevenson, “Optical Time of Flight and Absorbance Imaging of Biologic Media,”Science 259:1463-1466(1993).
Benaron and Stevens, “Resolution of Near Infrared Time-of-Flight Brain Oxygenation Imaging,”Oxygen Transport to Time XV, Edited by Vaupel et . Plemun Press, New York 345:609-617 (1994).
Brodbeck et al., “A System for Real Time Fluorescence Imaging in Color for Tumor Diagnosis,”Med Phys 14:637-639 (1984).
Bronstein et al., “Review Chemiluminescent and Bioluminescent Reporter Gene Assays.”Analytical Biochemistry 219:169-181 (1994).
Casedi et al., “Expression and Secretion of Aequorin as a Chimeric Antibody by Means of a Mammalian Expression Vector,”Proc. Natl. Acad. Sci. USA 87:2047-2051 (1990).
Chalfie et al., “Green Fluorescent Protein as a Marker for Gene Expression,”Science 263:802-805 (1994).
Chance et al., “Photon Dynamics in Tissue Imaging,”Proc. SPIE 1525:68-82 (1991).
Contag et al., “Optical Tracking of Infection in Vivo Using Light- Generating Probes,”Pediatric Research 37:172a (1994).
Cubeddu, et al., “Time-Gated Fluorescence Imaging for the Diagnosis of Tumors in a Murine Model,”Photochemistry and Photobiology 57(3): 480-485 (1993).
Cutler, M., “Transillumination as an Aid in the Diagnosis of Breat Lesions,”Gynecology and Obstetrics 48(6); 721-729 (1929).
Fernández-Piñas, et al., “Expression of luxCD-E inAnabaenasp. Can Replace the Use of Exogenous Aldehyde for in vivo Localization of Transcription by luxAB,”Gene 150: 169-174 (1994).
Folli et al., “Immunophotodiagnosis of Colon Carcinomas in Patients Injected with Fluoresceinated Chimeric Antibodies Against Carcinoembryonic Antigen,”Proc Natl Acas Sci 89:7973-7977 (1992).
Folli et al., “Antibody-Indocyanin Conjugates for Immunophotodetection of Human Squamous Cell Carcinoma in Nude Mice,”Cancer Research 54:2643-2649 (1994).
Frackman et al., “Cloning Organization and Expression of Bioluminescence Genes ofXenorhabdus luminescens,” Journal of Bacteriology 172(10):5767-5773 (1990).
Francis et al., “Light Emission for a Mudlux Transcriptional Fusion inSalmonella typhimurimis Stimulated by Hydrogen Peroxide and by Interaction with the Mouse Macrophage Cell Line J774.2,”Infection and Immunity 61(2):640-649 (1993).
Gimble et al., “In Vitro and in Vivo Analysis of Murine Lipoprotein Lipase Gene Promoter: Tissue-specific Expression,”American Journal of Physiology 268(2 Pt 1):E213-E218 (1995).
Goff et al., “Photoimmunotherapy and Biodistribution with an OC125-chlorin Immunoconjugate in an in vivo Murine Ovarian Cancer Model,”British Journal Cancer 70:474-480 (1994).
Gould et al., “Firefly Luciferase as a Tool in Molecular and Cell Biology,”Analytical Biochemistry 175:5-13 (1988).
Harats et al., “Targeting Gene Expression to the Vascular Wall in Transgenic Mice Using the Murine Proproendothelin-1 Promoter,”Journal of Clinical Investigation 95(3):1335-1344 (1995).
Hill et al., “Bioluminescence and Chemiluminescence Literature—Luciferase Reporter Genes—LuxandLuc”, Biolumin Chemilumin 8:267-281 (1993).
Hooper et al., “CCD Imaging of Luciferase Gene Expression in Single Mammalian Cells,”Journal of Bioluminescence and Chemiluminescence 5:123-130 (1990).
Hooper et al., “Low-light Imaging Technology in the Life Sciences,”J. Biolumin Chemilumin 9:113-122 (1994).
Horan et al., “Fluorescent Cell Labeling for in vivo and in vitro Cell Tracking,”Methods in Cell Biology 33:469-490 (1990).
Jarry et al., “Imaging Mammalian Tissues and Organs Using Laser Collimated Transillumination,”Journal of Biomedical Engineering 6:70-74 (1984).
Jassim et al., “In Vivo Bioluminescence: a Cellular Reporter for Research and Industry,”Journal of Bioluminescence and Chemiluminescence 5:115-122 (1990).
Jöbsis, “Noninvasive Infrared Monitoring of Cerebral and Myocardial Oxygen Sufficiency and Circulatory Parameters,”Science 198:1264-1267 (1977).
Kain et al., “Green Fluorescent Protein as a Reporter of Gene Expression and Protein Localization,”Biotechniques 19:65
Benaron David A.
Contag Christopher H.
Contag Pamela R.
Board of Trustees of the Leland Stanford University
Graser Jennifer E.
Robins & Pasternak LLP
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