Non-invasive localization of a light-emitting conjugate in a...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Diagnostic or test agent produces in vivo fluorescence

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S009100, C424S009610, C424S093100, C424S093200, C435S320100, C435S325000, C435S007900, C435S968000, C436S800000

Reexamination Certificate

active

06916462

ABSTRACT:
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

REFERENCES:
patent: 4178917 (1979-12-01), Shapiro
patent: 4341223 (1982-07-01), Lutz
patent: 4541438 (1985-09-01), Parker et al.
patent: 4762701 (1988-08-01), Horan et al.
patent: 4912031 (1990-03-01), Compton et al.
patent: 5171749 (1992-12-01), Levy et al.
patent: 5281539 (1994-01-01), Schramm
patent: 5283179 (1994-02-01), Wood
patent: 5332567 (1994-07-01), Goldenberg
patent: 5418132 (1995-05-01), Olivo
patent: 5435307 (1995-07-01), Friauf et al.
patent: 5466575 (1995-11-01), Cozzette et al.
patent: 5622868 (1997-04-01), Clarke et al.
patent: 5650135 (1997-07-01), Contag et al.
patent: 5683888 (1997-11-01), Campbell
patent: 5917190 (1999-06-01), Yodh et al.
patent: 6020121 (2000-02-01), Bao et al.
patent: 6217847 (2001-04-01), Contag et al.
patent: 0 350 973 (1984-01-01), None
patent: 0 263 657 (1988-04-01), None
patent: 0 743 366 (1996-11-01), None
patent: WO 86/01806 (1986-03-01), None
patent: WO 96/01805 (1986-03-01), None
patent: WO 91/01305 (1991-02-01), None
patent: WO 96/40979 (1996-12-01), None
Aizawa et al., “A New Diagnostic System for Malignant Tumors Using Hematoporhyrin Derivative, Laser Photoradiation and a Spectroscope,”Porphyrin Localization and Treatment of Tumorspp 227-238 (1984).
Alfano et al., “Fluorescence Spectra from Cancerous and Normal Human Breast and Lung Tissues,”Journal of Quantum Electronics23(10):1806-1811 (1987).
Alfano et al., “Light Sheds Light on Cancer-Distinguishing Malignant Tumors from Benign Tissues and Tumors,” Bull N.Y. Acad. Med. 67(2):143-150 (1991).
Anderson-Engles, S. et al., “Fluorescence Imaging and Point Measurements of Tissue; Applications to the Demarcation of Malignant Tumors and Atherosclerotic Lesions from Normal Tissue,”Photochemistry and Photobiology53(6):807-814 (1991).
Anderson-Engles, S. et al., “Laser Fluorescence in Malignant and Normal Tissue of Rats Injected with Benzoporhyrin Derivative,”Photochemistry and Photobiology57(6):978-983 (1993).
Andrew et al., “Construction of Bioluminescent Mycobacterium and its Use for Assay of Antimycobacterial Agents,”J. Clin. Microbiol.31(9):2251-2254 (1993).
Araki, “Photo-detection of Transferred Gene Expression in Fish,”Chemical Abstracts123: Abstract No. 189418 (1995).
Balchum, O. et al., “Imaging Fluorescence Bronchoscopy for Localizing Early Bronchial Cancer and Carcinoma in Situ,”Porphyrin Localization and Treatment of Tumors,pp. 847-861, New York: Alan R. Liss Inc. (1984).
Ballou, B. et al., “Tumor Location and Drug Targeting Using a Monoclonal Antibody (anti-SSEA-1) and Antigen-Binding Fragments,”Journal of Surgical Oncology31:1-12 (1986).
Ballou, B. et al., “Tumor Labeling In Vivo Using Cy5-monoclonal Antibody,”Proceedings of the American Association for Cancer Research Annual Meeting 35(0):504 (1994).
Baumgartner et al., “A Fluorescence Imaging Device for Endoscopic Detection of Early Stage Cancer- Instrumental and Experimental Studies,”Photochemistry and Photobiology:46(5):759-763 (1987).
Benaron et al., “A Medical Perspective at the Threshold of Clinical Optical Tomography,”SPIE Optical Engineering Press,pp. 3-9 (1993).
Benaron and Stevenson, “Optical Time of Flight and Absorbance Imaging of Biologic Media,”Science259:1463-1466 (1993).
Benaron and Stevens, “Resolution of Near Infrared Time-of-Flight Brain Oxygenation Imaging,”Oxygen Transport to Time XV,Edited by Vaupel et . Plenum Press, New York 345:609-617 (1994).
Brodbeck et al., “A System for Real Time Fluorescence Imaging in Color for Tumor Diagnosis,”Med Phys14:637-639 (1984).
Bronstein et al., “Review Chemiluminescent and Bioluminescent Reporter Gene Assays.”Analytical Biochemistry219:169-181 (1994).
Casedi et al., “Expression and Secretion of Aequorin as a Chimeric Antibody by Means of Mammalian Expression Vector,”Proc. Natl. Acad. Sci. USA87:2047-2051 (1990).
Chalfie et al., “Green Fluorescent Protein as a Marker for Gene Expression,”Science263:802-805 (1994).
Chance et al., “Photon Dynamics in Tissue Imaging,”Proc. SPIE1525:68-82 (1991).
Contag et al., “Optical Tracking of Infection in Vivo Using Light- Generating Probes,”Pediatric Research37:172a (1994).
Cubeddu, et al., “Time-Gated Fluorescence Imaging for the Diagnosis of Tumors in a Murine Model,”Photochemistry and Photobiology57(3): 480-485 (1993).
Cutler, M., “Transillumination as an Aid in the Diagnosis of Breast Lesions,”Gynecology and Obstetrics48(6); 721-729 (1929).
Fernández-Pi{hacek over (n)}as, et al., “Expression of luxCD-E in Anabaena sp. Can Replace the Use of Exogenous Aldehyde for in vivo Localization of Transcription by luxAB,”Gene150: 169-174 (1994).
Folli et al., “Immunophotodiagnosis of Colon Carcinomas in Patients Injected with Fluoresceinated Chimeric Antibodies Against Carcinoembryonic Antigen,”Proc Natl Acas Sci89:7973-7977 (1992).
Folli et al., “Antibody-Indocyanin Conjugates for Immunophotodetection of Human Squamous Cell Carcinoma in Nude Mice,”Cancer Research54:2643-2649 (1994).
Frackman et al., “Cloning Organization and Expression of Bioluminescence Genes ofXenorhabdus luminescens,” Journal of Bacteriology172(10):5767-5773 (1990).
Francis et al., “Light Emission for a Mudlux Transcriptional Fusion inSalmonella typhimuriumis Stimulated by Hydrogen Peroxide and by Interaction with the Mouse Macrophage Cell Line J774.2,”Infection and Immunity61(2):640-649 (1993).
Gimble et al., “In Vitro and in Vivo Analysis of Murine Lipoprotein Lipase Gene Promoter: Tissue-specific Expression,”American Journal of Physiology268(2 Pt 1):E213-E218 (1995).
Goff et al., “Photoimmunotherapy and Biodistribution with an OC125-chlorin Immunoconjugate in an in vivo Murine Ovarian Cancer Model,”British Journal Cancer70:474-480 (1994).
Gould et al., “Firefly Luciferase as a Tool in Molecular and Cell Biology,”Analytical Biochemistry175:5-13 (1988).
Harats et al., “Targeting Gene Expression to the Vascular Wall in Transgenic Mice Using the Murine Proproendothelin-1 Promoter,”Journal of Clinical Investigation95(3): 1335-1344 (1995).
Hill et al., “Bioluminescence and Chemiluminescence Literature—Luciferase Reporter Genes—Lux and Luc”,Biolumin Chemilumin8:267-281 (1993).
Hooper et al., “CCD Imaging of Luciferase Gene Expression in Single Mammalian Cells,”Journal of Bioluminescence and Chemiluminescence5:123-130 (1990).
Hooper et al., “Low-light Imaging Technology in the Life Sciences,”J. Biolumin Chemilumin9:113-122 (1994).
Horan et al., “Fluorescent Cell Labeling for in vivo and in vitro Cell Tracking,”Methods in Cell Biology33:469-490 (1990).
Jarry et al., “Imaging Mammalian Tissues and Organs Using Laser Collimated Transillumination,”Journal of Biomedical Engineering6:70-74 (1984).
Jassim et al., “In Vivo Bioluminescence: a Cellular Reporter for Research and Industry,”Journal of Bioluminescence and Chemiluminescence5:115-122 (1990).
Jöbsis, “Noninvasive Infrared Monitoring of Cerebral and Myocardial Oxygen Sufficiency and Circulatory Parameters,”Science198:1264-1267 (1977).
Kain et al., “Green Fluorescent Protein as a Reporter of Gene Expression and Protein Localization,”Biotechniques19:650-655 (1995).
Kaneko et al.,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Non-invasive localization of a light-emitting conjugate in a... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-invasive localization of a light-emitting conjugate in a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-invasive localization of a light-emitting conjugate in a... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3373430

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.