Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2006-09-26
2006-09-26
Jones, Dameron L. (Department: 1618)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001110, C424S001650, C424S001770, C424S001810, C424S001850, C424S009100
Reexamination Certificate
active
07112318
ABSTRACT:
The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with18F for non-invasive assessment of ΔΨm, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.
REFERENCES:
patent: 4446123 (1984-05-01), Woo
patent: 6190637 (2001-02-01), Ino et al.
patent: 6358489 (2002-03-01), Griffiths
patent: 2004/0092825 (2004-05-01), Madar et al.
P.C. Srivastava et al., “[(E)-1-[123l]lodo-1-penten-5-yl]triphenylphosphonium Iodide: Convenient Preparation of a Potentially Useful Myocardial Perfusion Agent.” J. Med. Chem., 1984, 27, pp. 978-981.
H. Fukuda et al., “Use of 11 C-triphenylmethylphosphonium for the evaluation of membrane potential in the heart by positron-emission tomography.” European Journal of Nuclear Medicine, 1986, 11: pp. 478-483.
B.J.Krause, “Myocardial Perfusion with [11C]Methyl Triphenyl Phosphonium: Measurements of the Extraction Fraction and Myocardial Uptake.” The Journal of Nuclear Biology and Medicine, vol. 38, No. 3, 1994, pp. 521-526.
I. Madar, et al., “Enhanced Uptake of [11C]TPMP in Canine Brain Tumor: A PET Study.” The Journal of Nuclear Medicine, vol. 40, No. 7, 1999, pp. 1180-1185.
I. Madar, et al., “Preferential Accumulation of 3H-Tetraphenylphosphonium in Non-Small Cell Lung Carcinoma in Mice: Comparison with 99mTc-MIBI.” The Journal of Nuclear Medicine, vol. 43, No. 2, 2002, pp. 234-238.
Dannals Robert Francis
Frost James J.
Madar Igal
Ravert Hayden T.
Scheffel Ursula A.
Corless Peter F.
Edwards Angell Palmer & & Dodge LLP
Jones Dameron L.
The Johns Hopkins University
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