Non-invasive determination of conditions in the circulatory...

Details Non-invasive determination of conditions in the circulatory... Non-invasive determination of conditions in the circulatory...

2006-07-04

2006-07-04

Nasser, Robert L. (Department: 3736)

Surgery

Diagnostic testing

Respiratory

C600S529000, C600S484000, C600S500000

Reexamination Certificate

active

07070569

ABSTRACT:
A method for non-invasively determining functional cardiac output (FCO) and/or venous blood CO2partial pressure (PvCO2). The amount of CO2(VCO2N) released from the blood and end capillary blood CO2content (CcCO2N) are determined from measurements from exhaled breathing gases. The CO2content of the breathing gases inhaled by the subject is increased and values for VCO2Rand CcCO2Rare obtained. A regression analysis is performed using the obtained VCO2N, VO2R, CcCO2N, and CcCO2Rvalues. The regression line is extrapolated to obtain a value for CcCO2when (VCO2) is zero so that CvCO2becomes known. The CvCO2thus determined can be inserted in a non-differential form in the Fick equation, along with VCO2and CcCO2values from normal breathing, to determine FCO. To determine PvCO2, CvCO2is altered in accordance with the amount of oxygen in the venous blood, to correctly indicate PvCO2. The continuing validity of the FCO measurement can be examined on a breath-by-breath basis by noting changes in an indicator variable, such as VCO2or end tidal CO2amounts.

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