Non-invasive blood glucose measurement system and method using s

Details Non-invasive blood glucose measurement system and method using s Non-invasive blood glucose measurement system and method using s

1990-12-14

1993-09-14

Cohen, Lee S.

Surgery

Truss

Pad

356301, 356 39, 351221, A61B 500, A61B 310, G01N 33483, G01J 344

Patent

active

052439836

ABSTRACT:
Stimulated Raman spectroscopy is used to non-invasively measure the concentration of an Raman active molecule, preferably D-glucose in the ocular aqueous humor of living being. The apparatus and method make use of two monochromatic laser beams, a pump laser beam and a probe laser beam. The output power of the pump laser beam is amplitude modulated, combined with the probe laser beam and directed into the ocular aqueous humor. The introduction of the laser beams into the ocular aqueous humor induces scattered Raman radiation, which causes a portion of the energy at the pump frequency to shift over to the probe frequency. The pump and probe laser beams are then detected as they exit the ocular aqueous humor. The probe laser beam is filtered, converted into an electrical signal and amplified. It is then compared to the modulation signal to generate an electrical signal representative of the concentration of D-glucose in the ocular aqueous humor.

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