Non-invasive approach for assessing tumors in living animals

Details Non-invasive approach for assessing tumors in living animals Non-invasive approach for assessing tumors in living animals

2005-08-09

2005-08-09

Nickol, Gary (Department: 1642)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S009100, C424S545000, C435S069100

Reexamination Certificate

active

06926890

ABSTRACT:
A means for following the growth of experimental neoplasms involves administering recombinant tumor cells containing an expression construct encoding a secretable marker to an experimental animal and measuring secreted marker in the urine of animals bearing tumors formed by such recombinant tumor cells. Urinary marker levels are quantitatively related to tumor loads. Urinary marker can be detected before tumors are grossly visible or clinically apparent. Marker levels decrease following surgical excision or chemotherapeutic treatment, with an estimated half-life of 11 hours. This approach is applicable to the study of many experimental tumor systems.

REFERENCES:
patent: 6419896 (2002-07-01), Vogelstein et al.
Marine et al., “Assessment of bystander effect potency produced by intratumoral implantation of HSVtk-expressing cells using surrogate marker secretion to monitor tumor growth kinetics”,Gene Therapy, (1995), 2, pp. 665-669.
Pesce et al., “Human Lactic Dehydrogenase as a Marker for Human Tumor Cells Grown in Athymic Mice”,Cancer Research,37, pp. 1998-2003, Jul. 1977.
Coimbra et al.,Braz. J. Med. Biol. Res.,vol. 17, 1984.
Umovitz et al.,Trends Biotech. Sci.,vol. 14, 1996.
Iles et al.,Prenat Diagn.,vol. 18, 1998, abstract only.

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