Non-intrusive process for monitoring the production of recombina

Details Non-intrusive process for monitoring the production of recombina Non-intrusive process for monitoring the production of recombina

1988-07-15

1991-06-04

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 4, 435 18, 435 681, 435 691, 435 711, 435 712, C12Q 102

Patent

active

050213377

ABSTRACT:
A process is described for monitoring the production of recombinant proteins. It is based on the discovery that infrared spectra of E. coli strains and transformants which overproduce recombinant proteins can be measured as a function of pressure, and a pressure-induced distinct shifting pattern can be observed in specific spectral parameters of transformants. In particular, the difference in the pressure-induced shift of the amide III band, between the E. coli cells and the transformants over-producing the recombinant proteins provides an efficient and non-intrusive technique for on-line monitoring of the production of recombinant proteins in E. coli.

REFERENCES:
Nichols et al.--J. of Microbiological Methods, vol. 4 (1985), pp. 79-94.

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