Non-insulin-dependent diabetic rat

Details Non-insulin-dependent diabetic rat Non-insulin-dependent diabetic rat

1995-12-06

1998-08-04

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

424 92, 800DIG4, 800DIG5, C12N 500, C12N 1500, A61K 4900

Patent

active

057896526

ABSTRACT:
This invention relates to a non-insulin-dependent diabetic disease model rat derived and established from Long-Evans rats, more particularly, a non-insulin-dependent diabetic rat having specific biochemical gene markers in organs, plasma and red blood cells, with erythrocytes and B lymphocytes having specific major histocompatibility antigen markers, showing increases in plasma glucose and insulin levels on oral glucose loading and increases in urinary protein level with aging, with diabetic nephropathy manifested by nodular and diffuse lesions of the glomerulus of the kidney accompanying in individuals with glycosuria.

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