Non-infectious, replication-impaired, immunogenic human immunode

Details Non-infectious, replication-impaired, immunogenic human immunode Non-infectious, replication-impaired, immunogenic human immunode

1995-06-06

1999-11-16

Scheiner, Laurie

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

4353201, 4241881, 4242081, C12N 704, C12N 1500, A61K 3921

Patent

active

059856416

ABSTRACT:
An immunogenic retrovirus-like particle which is non-infectious and non-replicating and which is useful as a candidate vaccine component against retroviral infections, including AIDS and ATLL, is produced by genetic engineering. A DNA molecule comprising a retroviral genome devoid of long terminal repeats is incorporated into an expression vector, which is introduced into mammalian cells for expression of the retrovirus-like particle.

REFERENCES:
patent: 5324645 (1994-06-01), Takahara et al.
D.D. Loeb et al, "Complete mutagenesis of the HIV-1 protease", pp. 397-400--see Abstract, Nature, vol. 340, No. 6232, Aug. 3, 1989.
Gowda, S. et al, J. Virol. 63(3):1451-1454, Mar. 1989.
Flexner, C. et al, Virology, 166:339-349, Oct. 1988.
Mazzara, G. et al, Abstract: Int. Conf. AIDS, Montreal, Canada, Jun. 4-9, 1989.
Shaw et al., "Eitology of AIDS: Virology, Molecular Biology, and Evolution of Human Immunodeficiency Viruses," in AIDS: Etiology, Diagnosis, Treatment, and Prevention, Second Edition, DeVita et al., eds., J. B. Lippincott Company, Philadelphia, p. 14 and 1988.
Rovinski et al., 1992, J. Virol. 66:4003-4012.
Haynes et al., 1991, AIDS Res. Hum. Retro. 7:17-27.
Karacostas et al., 1989, Proc. Natl. Acad. Sci. USA 86:8964-8967.

Affiliated with

Also associated with

Rating

Non-infectious, replication-impaired, immunogenic human immunode does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-infectious, replication-impaired, immunogenic human immunode, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-infectious, replication-impaired, immunogenic human immunode will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1323513