Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-05-06
1996-11-05
Budens, Robert D.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4241881, 4242081, 435 693, 4353201, 4351723, 536 2372, C12P 2106, A61K 3921, C07H 2104
Patent
active
055717128
ABSTRACT:
This invention is directed towards nucleic acid molecules capable of producing human immunodeficiency virus (HIV) retrovirus-like particles, which are non-infectious, replication defective, and immunogenic. Recombinant HIV genomes were generated that are devoid of long terminal repeats (LTRs) but contain a heterologous, inducible metallothionein promoter. Additional modifications have been made to the primer binding site, pol, vif, and env coding regions. Upon transfection into a suitable host these DNA molecules are capable of producing HIV retrovirus-like particles that lack genomic RNA. These non-infectious particles will provide suitable antigens for HIV diagnostic assays and immunogenic preparations.
REFERENCES:
patent: 5324645 (1994-06-01), Takahara et al.
Gowda, S. et al. J. Virol. 63(3): 1451-1454, Mar. 1989.
Flexner, C et al. Virology 166:339-349, Oct. 1988.
Mazzara, G et al. Abstract: Int. Conf. AIDS, Montreal, Canada Jun. 4-9, 1989.
Cao Shi X.
Haynes Joel
Klein Michel H.
Rovinski Benjamin
Budens Robert D.
Connaught Laboratories Limited
Parkin Jeffrey S.
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