Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-09-07
1999-01-19
Railey, II, Johnny F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4241881, 4241991, 4242081, 435 691, 4351723, 4352351, 435236, 4353201, 435325, 536 2372, C12N 510, C12N 1563, C12P 2102, C07K 14155
Patent
active
058612823
ABSTRACT:
This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.
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Aldovini Anna
Baltimore David
Feinberg Mark B.
Trono Didier
Young Richard A.
Railey II Johnny F.
Whitehead Institute for Biomedical Research
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