Non-infectious HIV particles and uses therefor

Details Non-infectious HIV particles and uses therefor Non-infectious HIV particles and uses therefor

1995-06-07

1999-07-06

Railey, II, Johnny F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4242081, 435 691, 4352351, 435236, 530826, A61K 3921, C07K 1416, C12N 1586

Patent

active

059194588

ABSTRACT:
This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.

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