Non-infectious foot-and-mouth disease viruses

Details Non-infectious foot-and-mouth disease viruses Non-infectious foot-and-mouth disease viruses

1995-04-07

1997-03-18

Budens, Robert D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242161, 435238, 435236, 536 2372, A61K 39135, C12N 704, C12N 706, C07H 2102

Patent

active

056120400

ABSTRACT:
A safe, effective vaccine for the protection of susceptible animals against foot-and-mouth disease has been produced. The vaccine comprises a mutant virus from which the amino acid sequence Gly-Val-Arg-Gly-Asp-Phe (SEQ ID NO: 8) from the G-H loop of VP1 has been deleted and replaced with the amino acid sequence Asn-Pro. The mutant virus retains its antigenicity but is not infectious.

REFERENCES:
Carreno et al. "Studies on antigenic variability of C Strains of foot-and-mouth disease virus by means of synthetic peptides and monoclonal antibodies" Int. J. Peptide Protein Res. 39, 1992, pp. 41-47.
Mason et al., Proc. Natl. Acad. Sci., vol. 91, pp. 1932-1936 (1994).
Novella et al., FEBS Letters, vol. 330(3), pp. 253-259 (1993).
Rieder et al., Journal of Virology, vol. 67(9), pp. 5139-5145 (1993).

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