Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2003-04-04
2008-01-01
Salimi, Ali R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S130100, C435S006120
Reexamination Certificate
active
07314629
ABSTRACT:
The invention relates to an immunogenic or vaccine composition inducing an immune response towards the HPV-16 Papillomavirus native E7 protein, without simultaneously inducing an immunosuppression, said composition comprising, as the active ingredient, a non immunosuppressive mutated E7 protein, comprising the amino acid sequence consisting, from the N-terminal end to the C-terminal end, in:i. the 1-19 amino acid sequence of sequence SEQ ID No. 3;ii. an amino acid sequence possessing (a) the substitution of at least one amino acid, compared to the 20-29 corresponding amino acid sequence of sequence SEQ ID No. 3 or (b) the deletion of at least four consecutive amino acids, compared to the 20-29 corresponding amino acid sequence of sequence SEQ ID No. 3; andiii. the 30-98 amino acid sequence of sequence SEQ ID No 3.
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Bizzini Bernard
Le Buanec Hélène
Zagury Daniel
Jacobson & Holman PLLC
Neovacs
Salimi Ali R.
LandOfFree
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